惠州市不同年龄段肺结核患者耐药情况分析

Drug Resistance in Patients with Pulmonary Tuberculosis at Different Ages in Huizhou City

目的：分析惠州市不同年龄段肺结核患者耐药情况，为耐药肺结核的诊断与治疗提供参考依据。方法抽取2010-2013年惠州市结核病防治研究所结核科收治的肺结核患者1484例，按照年龄分为18~35岁组356例，36~59岁组612例，≥60岁组516例。回顾性分析3组患者一线抗结核药物耐药情况及耐多药情况。结果18~35岁组患者异烟肼（ INH）和链霉素（ SM）耐药率均高于36~59岁组，INH、利福平（ RFP）、SM、乙胺丁醇（ EMB）耐药率和总耐药率均高于≥60岁组（P﹤0.05）；36~59岁组患者RFP耐药率高于≥60岁组（P﹤0.05）。18~35岁组患者耐多药率高于36~59岁组，耐3药、耐4药和耐多药率高于≥60岁组（ P﹤0.05）。结论惠州市不同年龄段肺结核患者耐药情况存在较大差异，青年患者容易形成获得性耐药，需采取有针对性的预防和监控措施。

Objective To analysis the drug resistance in patients with pulmonary tuberculosis at different ages in Huizhou city,to provide references for diagnosis and treatment of drug resistant tuberculosis. Methods From 2010 to 2013,1 484 pulmonary tuberculosis patients were randomly chosen in the Tuberculosis Institute of Huizhou,and then divided into 18-35 years old group of 356 cases,36-59 years old group of 612 cases,≥60 years old group of 516 cases. The drug resistant rate of first-line anti-tuberculosis drugs and multi-drugs resistant rate of 3 groups were retrospectively analyzed. Results INH and SM resistant rates of 18-35 years old group were higher than those of 36-59 years old group,INH,RFP,SM,EMB resistant rates and total drug resistant rate were higher than those of ≥60 years old group（P﹤0. 05）;the RFP resistant rate in 36-59 years old group was higher than that of ≥60 years old group （ P﹤0. 05 ） . The multi-drugs resistant rate of 18 -35 year old group was higher than that of 36-59 years old group,3 drugs resistant rate,4 drugs resistant rate and multi-drugs resistant rate were higher than those of≥60 years old group（P﹤0. 05）. Conclusion There is a big difference of drug resistance in patients with pulmonary tuberculosis at different ages in Huizhou city,while young patients are easy to get acquired drug resistance,for which is necessary to take individual measures to prevent and control.