高渗盐水对危重症手足口病患儿的治疗作用

EFFECTS OF HYPERTONIC SALINE IN THE TREATMENT OF CHILDREN WITH CRITICAL HAND,FOOT AND MOUTH DISEASE

目的：探讨高渗盐水在危重症手足口病患儿治疗中的应用效果。方法对2011年1月～2013年1月在我院进行治疗的250例手足口病患儿随机分组，对照组患儿给予常规治疗，实验组患儿在常规治疗的基础上给予高渗盐水治疗。观察比较两组患儿的治疗效果、钠离子浓度。结果实验组患儿的治疗效果明显优于对照组（p＜0.05）；治疗前两组患儿的钠离子浓度和不良反应发生率未见显著性差异（p＞0.05），治疗第4天和第6天实验组患儿的钠离子浓度明显高于对照组（p＜0.05）。结论针对危重症手足口病患儿采用高渗盐水治疗可以明显提高治疗效果，提高患儿的钠离子浓度，改善预后。高渗盐水治疗危重症手足口病具有十分重要的临床意义，值得推广应用。

Objective To investigate the effects of hypertonic saline in the treatment of children with critical hand, foot and mouth disease （HFMD）.Methods The 250 pediatric patients with HFMD hospitalized from January 2011 to January 2013 in our hospital were randomized into the control group treated routinely and the experimental group treated with hypertonic saline on the basis of general conventional treatment .The therapeutic effect and sodium ion concentration in the children of two groups were observed and compared.Results The treatment effect of the experimental group was obviously better than that of the control group （p〈0.05）.Sodium ion concentration and incidence of adverse reactions in two groups before treatment showed no significant differences （p〉0.05）, while the sodium ion concentration of the experimental group was much higher than that of the control group on the 4th and 6th treatment day （p〈0.05）.Conclusion Hypertonic saline treatment can significantly enhance the therapeutic effect, increase the sodium ion concentration and improve the prognosis in children with critical HFMD.Therefore, hypertonic saline treatment for patients with clinical HFMD has a very important clinical significance and it is worth popularization and application.