利培酮与氯氮平对精神分裂症患者脑电图的影响

CONTRAST ANALYSIS OF RISPERIDONE AND CLOZAPINE ON EEG OF PATIENTS WITH SCHIZOPHRENIA

目的分析利培酮与氯氮平对精神分裂症患者脑电图的影响。方法通过对两组分别服用氯氮平、利培酮的患者,在服药前、服药后第2周、第4周分别检查脑电图一次,分析两组病人脑电图的异常率,对比两种药物对脑电活动的影响。结果氯氮平引起脑电图异常率明显高于利培酮(p<0.05)。结论利培酮对脑电图的影响较氯氮平轻。

Objective To analyze the effects of risperidone and clozapine on EEG of patients with schizophrenia. Methods The two groups of patientstaking clozapine and risperidone respectively were given EEG examination before and after 2nd and 4th week of treatment, the abnormal rate of EEG of two groups of patients were analyzed to compare the effects of the two drugs on electrical activity of the brain.Results The abnormal rate of EEG induced by clozapine was significantly higher than that induced by resperidone （p〈0.05）.Conclusion The influence of risperidone on EEG is lower than that of clozapine.