长期服药精神病患者双肾下极脂肪囊的超声评价

Ultrasound Measurement of Inferior Pole Area of Perirenal Fat in Psychiatric Patients with Long-Term Medication

目的探讨双肾下极脂肪囊(inferior pole area of perirenal fat,IPAPF)可否作为长期服抗精神病药患者心血管病的危险因素。方法纳入106例长期服药精神病患者作为研究组,112例体检人群作为对照组,比较两组一般资料、血脂及超声测量IPAPF。结果研究组HDL-C明显低于对照组,双肾下极脂肪囊面积明显高于对照组,差异有统计学意义(P<0.05)。两组间TC、TG、LDL-C、FBD差异没有统计学意义(P>0.05)。HDL-C、双肾下极脂肪囊呈负相关(r=-0.37,P<0.01)。结论双肾下极脂肪囊与反映冠心病风险的指标存在相关,因此超声测量双肾下极脂肪囊能反映长期服抗精神病药患者心血管病的风险。

Objective To investigate whether the inferior pole area of perirenal fat （IPAPF） to be used as a cardiovascular disease risk factor of patients taking long-term antipsychotic drugs. Methods 106 psychiatric patients with long-term medication and 112 healthy people were recruited as study group and control group respectively. Demographic data, lipid and ultrasonic IPAPF were measured in two groups. Results HDL-C of study group was significantly lower than that of control group, and IPAPF was significantly higher than that of control group （P〈0.05）, without significant difference in TC, TG, LDL-C, FBD between two groups （P 〉0.05）. IPAPF was negatively correlated with HDL-C （r=-0.37, P 〈0.01）. Conclusions IPAPF associates with index reflecting the risk of cardiovascular disease, so the ultrasound measurement of IPAPF can reflect the risk of cardiovascular in patients with long-term antipsychotic therapy.