大剂量奥美拉唑治疗老年胃溃疡合并出血疗效分析

Efficacy Analysis of High-Dose Omeprazole in the Treatment of Elderly Patients with Gastric Ulcer Complicated with Hemorrhage

目的分析大剂量奥美拉唑治疗老年胃溃疡合并出血的疗效。方法选择2009年6月至2012年6月我院收治的78例老年胃溃疡合并出血患者作为研究对象,随机分成两组各39例,观察组使用大剂量奥美拉唑治疗,对照组使用常规剂量的奥美拉唑进行治疗,比较两组的疗效以及并发症的发生情况。结果治疗后观察组患者的再次出血率明显低于对照组(P<0.05);观察组患者治疗后总有效率显著高于对照组(P<0.05)。两组患者的并发症发生情况比较无显著差异(P>0.05)。结论采用大剂量奥美拉唑治疗老年胃溃疡合并出血患者,能有效提高患者的临床治疗效果,同时降低了再出血的风险,适合在临床推广应用。

Objective To analyze the curative effect of high-dose omeprazole in the treatment of elderly patients with gastric ulcer complicated with hemorrhage. Methods 78 cases of elderly patients with gastric ulcer complicated with hemorrhage in our hospital from June 2009 to June 2012 were selected as the research objects and randomly divided into two groups, with 39 cases in each group. Patients in the observation group were treated with high-dose omeprazole, while patients in the control group were treated with normal-dose omeprazole. The curative effect and complication were compared between two groups. Results The incidence of re-bleeding of observation group was significantly lower than that of control group （P〈0.05）. The total effective rate of observation group was 94.87%, significantly higher than 76.92%of control group （P 〈0.05）, but there was no statistical difference between two groups in the incidence of complications （P〉0.05）. Conclusions High-doses of omeprazole for the treatment of elderly patients with gastric ulcer complicated with hemorrhage, can effectively improve the clinical curative effect, and reduce the incidence of re-bleeding, which is worthy of clinical promotion.