老年急性白血病临床特点及个体化治疗分析

Clinical Features and Individual Therapy Analysis of Elderly Patients with Acute Leukemia

目的对老年急性白血病的临床特点及个体化治疗进行分析。方法选取老年急性白血病患者80例,按照第一次诱导缓解中化疗药物的用量将患者分为标准或亚标准计量组(A组)和小剂量组(B组),对两组患者的治疗效果进行综合评价。结果A、B两组患者完全缓解(CR)率分别为22.5%和45.0%,总有效率分别为57.5%和80.0%,平均生存时间分别为(175.6±20.3)d和(203.9±29.4)d,平均骨髓抑制持续时间分别为(22.4±6.3)d和(12.5±4.6)d,以上差异均具有统计学意义(P<0.05);不良反应发生率分别为92.0%和88.0%,差异无统计学意义(P>0.05)。结论老年急性白血病患者对化疗的耐受性较差,早期的死亡率比较高,生存时间短,需要对患者实施个体化治疗。

Objective To explore the clinical features and analyze the individualized treatment of elderly patients with acute leukemia. Methods 80 cases of elderly patients with acute leukemia were selected and divided into standard or sub-standard measurement group （group A） and low-dose group （group B）, based on the amount of first remission induction chemotherapy drugs. After treatment, the efficacies of two groups of were evaluated. Results Complete remission （CR） rates of the two groups were 22.5%and 45.0%;total efficacy was 57.5%and 80.0%, average survival time was （175.6±20.3） d and （203.9±29.4） d;average bone marrow suppression time was （22.4±6.3） d and （12.5 ± 4.6） d, with statistically significant difference （P 〈0.05）. Adverse reactions rates were 92.0% and 88.0%, without statistically significant difference （P〉0.05）. Conclusions For elderly patients with acute leukemia, tolerance of chemotherapy is poor, early mortality is high, and survival time is short, so elderly patient with acute leukemia should be given individualized treatment.