新生儿缺氧缺血性脑病108例临床分析

Clinical analysis of 108 cases of newborn hypoxic-ischemic encephalopathy

目的探讨新生儿缺氧缺血性脑病(HIE)的诊断及治疗方法。方法对108例HIE的病因、发病机制、临床表现、辅助检查及治疗方法和治疗效果做回顾性分析。随机将108例HIE分为4组,每组27例。综合性治疗基础上,分别应用神经节苷脂(GM-1)、胞二磷胆碱、硫酸镁治疗。结果 HIE的诊断主要靠临床表现。B超、CT、MRI检查有助于HIE的诊断。GM-1、胞二磷胆碱疗效显著,分别与对照组对比差异有统计学意义(P<0.01,P<0.05)。结论 MRI检查有利于判断HIE病情及预后,分别应用GM-1、胞二磷胆碱治疗HIE疗效好,值得临床推广。

Objective To explore the methods for diagnosis and treatment of newborn hypoxic ischemic encephalopathy （HIE）.Methods The etiology ,pathogenesis ,clinical manifestations ,auxiliary examination ,the methods of treatment and therapeutic effect of 108 cases of HIE were retrospectively analyzed.108 cases of HIE were randomly divided into four groups , 27 cases in each group. On the basis of comprehensive treatment ,each group was treated with ganglioside （GM-1） or cytidine diphosphate choline or magnesium sulfate respectively.Results The diagnosis of HIE mainly depended on clinical manifesta-tions. It was helpful to the diagnosis of HIE to take the examination of B ultrasound ,CT and MRI. GM-1 or cytidine diphos-phate choline had significant effectiveness ,compared with the control group respectively. There was statistically significant difference （AP〈0.01 BP〈0.05）.Magnesium sulfate had certain curative effect.Conclusion Examination of MRI helps deter-mine the severity and prognosis of HIE. There is a good effectiveness to use the GM-1 or cytidine diphosphate choline ,and It is worthy of clinical promotion.