尼莫地平治疗蛛网膜下腔出血后脑血管痉挛的临床疗效观察

Observation on the effect of nimodipine in the treatment of cerebral vasospasm after subarachnoid hemorrhage

目的探讨尼莫地平治疗蛛网膜下腔出血(SAH)后脑血管痉挛(CVS)的临床疗效。方法选取2009-05—2013-07我院收治的SAH后CVS患者178例为研究对象,观察组96例行尼莫地平治疗,其余82例为对照组。采用GCS评分和改良Rankin’s评分量表(mRS)评价2组治疗情况;复查CTA评价脑血管痉挛的缓解率。结果 GCS评分中观察组治疗有效率为87.5%,明显高于对照组的63.4%(P<0.05),mRS评分观察组良好率为89.6%,明显高于对照组的70.7%(P<0.05);观察组治疗后脑血管痉挛的缓解率也高于对照组(P<0.05)。结论尼莫地平能有效改善蛛网膜下腔出血后脑血管痉挛的症状,提高生存率,改善患者生活质量。

Objective To investigate the clinical effect of nimodipine in treatment of cerebral vasospasm after subarachnoid hemorrhage.Methods One hundred and seventy-eight patients with cerebral vasospasm after subarachnoid hemorrhage collect-ed from May 2009 to July 2013 were selected ,and were randomly divided into two groups ,with 96 cases in the observation group and 82 cases in the control group. GOC scores and modified Rankin’s scores （mRS） were used to estimate the clinical effect of the two groups ,and CTA was reexamined to estimate the remission rate of cerebral vasospasm.Results The effective rate of GCS in the observation group was 87.5% ,which was significantly higher than 63.4% in the control group （P〈0.05 ）.The good effect rate of mRS in the observation group and the control group was 89.6% and 70.7% ,respectively ,with a sig-nificant difference （P〈0.05）. And the remission rate of CVS after treatment in the observation group was significantly higher than that in the control group （P〈0.05）.Conclusion Nimodipine can significantly relieve the symptoms of CVS after SAH , and increase the survival rate and improve the living quality of patients.