微小RNA与宫颈癌

MicroRNA and Cervical Cancer

微小RNA(microRNA,miRNA)是一类内源性非编码调节性小RNA,通过与3′非转录区(3′UTR)互补配对来调节其靶基因的蛋白翻译或者mRNA降解过程,从而在转录后水平调节靶基因的表达。成熟的miRNA通过调节靶基因的表达行使其生物学功能,参与细胞增长、细胞凋亡等多种细胞癌变过程。研究表明,miRNA在宫颈癌中的差异性表达有可能使其成为诊断、临床病理学特征和评价预后的新指标。miRNA也可以用于指导治疗以及成为治疗用药的靶点,为临床应用提供广泛前景。

MicroRNA （miRNA）, a class of endogenous small non-coding regulatory RNAs, regulate the expression of target genes by pairing with its 3＇untranslated regions （3＇UTR） to induce the inhibited translation or mRNA degression. Mature miRNA may interfere with multiple biological processes involved in tumorigenesis such as cell proliferation, cell cycle, apoptosis, angiogenesis, invasion and metastasis. Multiple studies showed that the aberrant expression of miRNA, as novel potential makers, could provide numerous promising merits in diagnostic, pathological and therapeutic targets in cervical cancer.