摘要
亲吻肽为G蛋白偶联受体54(GPR54)的内源性配体,其C末端为精氨酸-苯丙氨酸-NH2(RFamide)。促性腺激素抑制激素(GnIH)的受体为GPR147,其C末端亦为RFamide。雌激素通过上调脑内亲吻肽的表达,促进促性腺激素释放激素(GnRH)分泌。GnIH对GnRH亦可发挥直接作用,在下丘脑和垂体两个水平上抑制促性腺激素的合成和分泌。十余年来越来越多的证据证实,这两条C末端为RFamide的调节性神经肽(RF酰胺肽)能直接作用于GnRH神经元,并相互拮抗地参与性类固醇激素对生殖轴的反馈调控。
Kisspeptin is an endogenous ligand of G protein-coupled receptor 54（GPR 54）.Its C-terminal structure is Arg-Phe-NH2（RFamide）.Gonadotropin-inhibitory hormone（GnIH） is a dodecapeptide also with the RFamide structure in its C-terminus.Its receptor is GPR147.Through up-regulation of kisspeptin expression in brain,estrogen promotes the secretion of gonadotropin-releasing hoone （GnRH）.GnIH can also play a direct role on GnRH with inhibitory effects on the synthesis and secretion of gonadotropin on two levels of hypothalamus and pituitary.In the past decade,more and more evidences indicated that these two regulatory neuropeptides with the RFamide structure in their C-termini can act directly on the GnRH neurons,antagonistically involved in the feedback regulation of sex steroid hoones on the reproductive axis.
出处
《医学综述》
2014年第14期2505-2507,F0003,共4页
Medical Recapitulate
基金
中国检科院基本科研业务费专项资金资助项目(2010JK023
2012JK043)
