肥胖与胃癌的相关机制及临床研究

Obesity and Gastric Cancer: Mechanisms and Clinical Research

肥胖和肿瘤是全球两大重要的公共卫生问题,每年给社会造成了沉重的经济负担。目前研究发现,肥胖可以增加包括胃癌在内的多种恶性肿瘤的罹患率,并且还指出肥胖患者治疗效果差、肿瘤相关病死率高,但具体机制尚不清楚。近年研究表明,肥胖与胃癌相关的机制可能有胃食管反流、慢性炎症、幽门螺杆菌感染、胰岛素抵抗、肥胖相关因子等,并且还发现肥胖与胃癌患者的手术并发症、预后等有关。

Obesity and cancer are two major global public health problems,which bring heavy economic burden to the world.Current epidemiological studies indicate obesity is associated with increasing incidence of several cancer types including gastric cancer.The treatment effect of the obesity patient is usually not good and the cancer-related mortality rate is high,although the mechanism remains unclear.Recent research also reveals possible mechanisms linking obesity with gastric cancer may include gastro-oesophageal reflux,chronic inflammation,Helicobacter pylori infection,insulin resistance,obesity-related factor and so on.Besides,obesity in patients with gastric cancer is associated with surgical complications and prognosis.