非痴呆老年人海马CA1区阿尔茨海默病样病理改变与动脉粥样硬化的关系

The relationship between atherosclerosis and Alzheimer-like pathologic changes in the CA1 field of hippocampus in old non-demented persons

目的 探讨非痴呆老年人海马CA1区Alzheimer病 (AD)样病理改变与动脉粥样硬化的关系。方法 以我院1986年 1月 1日～ 2 0 0 0年 4月 1日年间的全身尸检病例为基础 ,选择病史中无痴呆及精神异常记录的病例共 112例为研究对象 ,记录主动脉、冠状动脉、脑底动脉和大脑后动脉的硬化程度。在外侧膝状体平面取双侧海马 ,经固定、切片后 ,分别进行HE、硝酸银染色 ,应用图象分析仪 ,分别记录老年斑、神经原纤维缠结、平野小体、颗粒空泡变性在海马CA1区的分布情况 ,统计分析老年斑、神经原纤维缠结、平野小体、颗粒空泡变性的密度 (个 mm2 )、出现率与各动脉粥样硬化的关系。结果 海马CA1区老年斑、神经原纤维缠结、平野小体、颗粒空泡变性的密度(个 mm2 )出现率与各动脉粥样硬化的程度无关 ,P值均 >0 .0 5。

Objective To find the relationship between atherosclerosis and Alzheimer like pathologic changes in the CA1 field of hippocampus in old non demented persons.Methods Alzheimer like neuropathologic changes in the CA1 field of hippocampus and atherosclerosis of the aorta,coronary and cerebral arteries were examined and analysed in non demented individuals older than 60 years of age at autopsy from Jan 1,1986 to Apr 1,2000.Results Among 112 consecutive autopsies,no correlation was found between the severity of atherosclerosis of the aorta,coronary arteries,or cerebral arteries and the prevalence and densities of senile plaques,neurofibrillary tangles,Hirano bodies and granulovacuolar degeneration in the CA1 field of hippocampus.Conclusion There was no relationship between atherosclerosis and Alzheimer like neuropathologic changes in the CA1 field of hippocampus.