代谢综合征对中老年人群踝臂指数的影响

The impact of the metabolic syndrome on the anlde-brachial index in the elderly population

目的探讨代谢综合征（MS）对中老年人群踝臂指数（ABI）的影响。方法采用前瞻性队列研究，在2006—2007年参加健康体检的101510例开滦集团职工中随机分层抽取5852例作为研究对象，进行统一问卷调查及血液生化检查，符合入选标准的为5440例。于2010—2011年度进行第3次健康体检并测量ABI，最终纳入统计分析的有效数据为4729例。依据2007年中国成人血脂异常防治指南对2004年CDS建议的修订作为诊断标准，将研究人群分为MS组和非MS组，对影响ABI的相关危险因素进行多因素Logistic回归分析。结果MS组和非MS组的平均ABl分别为1．09±0．11、1．09±0．09，组间比较差异无统计学意义（P=0．807）。ABI≤0．9分别为49例（5．2％）、120例（3．2％），组间比较差异有统计学意义（x2=7．41，P〈0．05）；影响ABI的多因素logistie回归分析显示：ABI≤0．9、男性人群与MS患者具有相关性（RR：1．48，95％CI：1．04—2．08、RR：1．56，95％CI：1．02—2．37；P均〈0．05）。结论在中老年人群MS是影响远期ABI的独立危险因素，且在男性中更加显著。

Objective To investigate the impact of metabolic syndrome （MS） in the elderly ankle- brachial index（ABI）. Methods A prospective cohort study was conducted. Five hundred and eighty-two people from 101 510 cases who participated in the 2006 -2007 of healthy Kailuan Group employees by stratified random decimation were selected as subjects. Unified questionnaires and blood tests were performed and 5 440 cases met the inclusion criteria. ABI was measured from 2010 to 2011 at the third health examination and 4 729 final valid data were used to make statistical analysis. Based on 2007 Chinese adult dyslipidemia prevention guide for 2004 CDS of the proposed amendments as diagnostic criteria, the study population was divided into MS group and non- MS group. Multivariate logistic regression was used to identify the risk factors. Results The average ABI in MS group and the non-MS group were （ 1.09 ± 0. 11 ）, （ 1.09 ± 0. 09）, and the difference between groups was not statistically significant（ P = 0. 807 ）. The rate of people with ABI 〈 0. 9 in MS group and the non-MS group were 49（5.2% ） and 120 （5.2%）, and the difference between groups was statistically significant （ X2 = 7.41, P 〈 0.05 ）. Multivariate logistic regression analysis showed that the factors of male and ABI 〈 0. 9 were related to MS（ （RR：l.48,95%CI：l. O4-2.08;RR：l.56,95%CI：l. O2-2.37;P 〈O. O5）. Conclusion In the elderly population, MS is an independent risk factor which impact on ABI especially in male population.