核因子-κB与肿瘤放射治疗

NF-κB in neoplasms radiotherapy

核因子-κB（NF-κB）是哺乳动物真核细胞中重要的转录因子，在机体免疫、炎症以及肿瘤的发生发展、浸润转移、肿瘤细胞凋亡方面起着重要作用。近年来研究发现，NF-κB在肿瘤中高表达与肿瘤耐放射治疗及预后差密切相关，NF-κB可作为评价放疗疗效及预后的指标。针对NF-κB激活的通路，可以从不同的方面寻找药物抑制NF-κB的激活，提高放疗疗效。

NuclearfactorκB（NF-κB）isanimportanttranscriptionfactorinmammaliancells.Asa multifunctional factor,NF-κB is involved in a variety of physiological and pathological processes such as immu-nity and inflammation .At the molecular and cellular level,NF-κB regulates initiation and progression of neo-plasms.NF-κB also plays an important role in cell proliferation and apoptosis of neoplasms.Radiotherapy is one of the most important methods in tumor treatment .In recent years,a number of studies discovered that NF-κB is critical in the development of resistance of tumor cells to radiotherapy,which results in poor progno-sis.We can use NF-κB as a biomarker in predicting outcomes of anticancer treatment or as prognostic indicators in patients who are with tumors.So we can find different potential inhibitors aimed at NF-κB and its signal pathway in order to improve the efficacy of radiotherapy.In the present study,the correlation of NF-κB mole-cules with radiotherapy of neoplasms is reviewed.