炎症反应与微小RN A差异性表达在肺癌中的研究进展

The research on inflammatory reaction and differential expression of microRNAs in lung caner

微小RNA（miRNA）是一类单链非编码RNA，直接与靶基因mRNA互补结合导致靶分子mRNA翻译受到抑制以降低靶基因的表达，参与细胞的分化、增殖、凋亡等过程。miRNA既参与调节炎症反应，也在肿瘤的形成中发挥重要作用。炎症反应与miRNA相互作用导致miRNA差异性表达引起肺癌的研究受到广泛关注。炎症反应与miRNA差异性表达机制研究的不断深入，有望给肺癌的预防、诊断及治疗带来新的策略。

MicroRNAisatypeofsingle-strandednon-codingRNA,directlybondingtothecomplemen-tary target gene mRNA.That leads to the inhibition of mRNA translation of the target molecule in order to reduce expression of the target gene.MicroRNAs are not only involved in the regulation of inflammatory reac-tion,but also play important roles in the formation of neoplasm.The researches showing that the inflammatory reaction interacting with miRNAs results in the differential expressions of microRNAs in lung cancer have been widespreadly concerned.Along with the deepening of the research on the mechanisms of inflammatory reaction and differential expression of microRNAs,it will provide new strategies for the prevention,diagnosis and treat-ment of lung cancer.