OSAHS与肺动脉高压的相关性研究

The correlation between obstructive sleep apnea hypopnea syndrom and pulmonary hypertension

目的评价OSAHS对肺动脉压及右心功能的影响。方法选择OSAHS患者72例和正常鼾症组23例，分别行多导睡眠呼吸监测和超声心动图测定心脏结构、血流动力学参数并估算肺动脉压。结果72例OSAHS患者中肺动脉高压（PH）的发生率为38．89％，23例鼾症组中PH的发病率为17．39％，且OSHAS组患者右心结构及血流动力学变化程度均明显高于鼾症组（P〈0．05或P〈0．01），OSAHS患者肺动脉压、右心结构及血流动力学变化与OSAHS严重程度相关。结论OSAHS患者中PH的发生率较高，OSAHS同时合并PH的患者其右心结构变化较明显；OSAHS患者的肺动脉压力升高程度和右心结构变化程度与OSAHS的严重程度呈正相关。

Objective To evaluate obstructive sleep apnea hypopnea syndrom （OSAHS） on pulmonary hypertension （PH） and right heart function. Methods Seventy-two patients with OSAHS and 23 snoring patients were determined by polysomnograpby and echocardiographic to evaluate heart structure,hemodynamic parameters measurement and pulmonary hypertension PH. Results Seventy-two patients with OSAHS in the incidence of PH, right heart structure and hemodynamic changes were significantly higher than that of 23 snoring patients （ P 〈0.05 or P 〈0.01） ,OSAHS patients with PH, right heart structure and hemodynamie changed good correlation with OSAHS severity. Conclusions The incidence of OSAHS patients with PH was higher,patients with OSAHS combined PH at the same time whose right heart structure changed was obvious. Severity of PH and right heart structure was changed with the severity of OSAHS.