维持性血液透析患者体内微炎症指标变化的探讨

Change of microinflammatory indicators in maintenance hemodialysis patients

目的探讨维持性血液透析患者体内微炎症指标的变化情况,为临床治疗提供新思路。方法检测80例血透患者血清超敏C反应蛋白(hs-CRP)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)、同型半胱氨酸(Hcy)、丙二醛(MDA)、清蛋白(ALB)、转铁蛋白(Tf)、血红蛋白、全段甲状旁腺素(iPTH)水平,并与健康体检人群进行比较。结果维持性血液透析患者体内hs-CRP、IL-6、TNF-α水平明显高于健康人群(P<0.05),hs-CRP水平与IL-6、TNF-α、Hcy、MDA、iPTH水平呈正相关,而与ALB、Tf水平呈现负相关。结论维持性血液透析患者体内微炎症指标高于健康人,急需进行相关治疗。

Objective To investigate the changes of microinflammatory indicators in the maintenance hemodialysis patients to provide the new idea for clinical treatment.Methods Serum super sensitive C reactive protein （hs-CRP）,interleukin 6（IL-6）,tumor necrosis factorα（TNF-α）,homocysteine（Hcy）,malondialdehyde（MDA）,albumin（ALB）,hemoglobin,transferrin（Tf）levels and in-tact parathyroid hormone（iPTH）levels in 80 patients with hemodialysis were detected and the results were compared with those in the normal healthy population.Results The hs-CRP,IL-6,TNF-αlevels in the maintenance hemodialysis patients were significantly higher than those in the normal healthy population （P 〈0.05 ）,the CRP level was positively correlated with IL-6,TNF-α,Hcy, MDA and iPTH levels and negatively correlated with ALB and Tf levels.Conclusion The microinflammatory indicators in the ma-intenance hemodialysis patients are higher than those in the normal people,which urgently need to conduct the related treatment.