重症监护室患者血清降钙素原与CRP相关指标测定的临床意义

Clinical significance of determination of serum procalcitonin and CRP related indexes in ICU patients

目的：探讨血清降钙素原监测在判断重症患者是否并发感染的的价值。方法收集重症监护病房（ICU）188例患者分为感染组和未感染组，同时监测血清 PCT、CRP、白细胞总数和中性粒细胞比值；感染组中41例患者连续1～6 d 动态测定 PCT及相关指标，并进行统计学分析。结果重症感染组（112例）和重症非感染组（76例）的年龄、PCT、CRP 比较差异有统计学意义；除感染组 PCT 和 CRP 相关性比较有统计学意义外，其他指标比较差异无统计学意义（P ＞0．05）；感染者中出院组（32例）和死亡组（9例），第1、2天两者 PCT 值比较 P ＞0．05，第3～6天 PCT 值比较，差异有统计学意义（P ＜0．05）。结论血清 PCT 是判断重症患者感染与否的有效指标，独立并且明显优于传统的炎症指标，在重症患者中动态监测其水平对判断感染的控制情况具有一定价值。

Objective To explore the value of serum procalcitonin detection in judging whether severe patients complicate with infection.Methods 188 patients in the intensive care unit （ICU）were collected and divided into the infection and non-infection groups.The serum procalcitonin（PCT）,C-reactive protein（CRP）,total number of white blood cells（WBC）and neutrophile cell ratio were simultaneously monitored;41 cases in the infection group dynamically monitored PCT and related indicators for continuous 1-6 d and the statistical analysis was conducted.Results The age,PCT and CRP had statistically significant differences between the infection group（112 cases）and non-infection group（76 cases）.Except the correlation of PCT and CRP in the infection group showing statistical significance,the comparison of the other indicators had no statistical differences.In the infectors,the PCT value comparison between on 1 d and 2 d in the hospital discharge group（32 cases）and the death group （9 cases）showed P 〉0.05,the PCT value comparison between on 3-6 d showed P 〈0.05.Conclusion Serum PCT is an effective indicator to judge whether se-vere infected patient has infection and is significantly superior to the traditional inflammatory indicators.Dynamically monitoring the PCT level in the critical patients has a certain value to judge the control situation of infection.