深圳地区女性生殖道HPV感染及基因型结果分析

Analysis of women′s genital human papillomavirus infection and genotype distribution in Shenzhen

目的：研究深圳市宝安区女性人乳头瘤病毒（HPV）感染情况，以及不同年龄段 HPV 阳性率和各亚型的分布情况。方法采用聚合酶链式反应-反向斑点杂交法（PCR-RDB）对2011年1月至2012年12月在深圳市宝安区妇幼保健院就诊的患者（2627例）进行23种 HPV 基因分型检测。结果2627例样本中 HPV 阳性率为23．94％（629例）。其中单一低危型感染占15．10％，以 HPV43型为主；单一高危型感染占55．17％，以 HPV52、HPV16、HPV58型为主；混合感染占29．73％。15～＜21岁、21～＜31岁、31～＜41岁、41～50岁与＞50岁年龄组 HPV 感染率分别为50．0％、24．7％、20．8％、25．8％、42．1％，差异有统计学意义（P ＜0．05）。结论深圳市宝安地区 HPV 感染率为23．94％，基因型分布以 HPV 52、16、58、43型为主，15～20岁年龄段感染率高于其他年龄段。

Objective To investigate the female human papillomavirus（HPV）infection situation in Baoan district,the HPV pos-itive rates in different age groups and the subtypes distribution.Methods PCR followed with reverse dot blot was performed to ex-amine 23 kinds of HPV genotypes in 2 627 female patients in our hospital from the January 2011 to December 2012.Results In 2 627 samples,the positive rate of HPV was 23.94% （629 cases）,in which the infection rate of single low-risk type was 15.1%（95 cases）,the main HPV genotype was HPV43 （7.79%）;the infection rate of high-risk type was 55.17% （347 cases）,the 3 most prevalent HPV genotypes were HPV52 （12.56%）,HPV16 （9.86%）and HPV58 （7.79%）.The multiple HPV infection ac-counted for 29.73% （187 cases）.The HPV infection rates in different age groups were 50.0% in age 15-20 years,24.7% in age 21-30 years,20.8% in age 31-40 years,25.8% in age 41 -50 years,42.1% in age ＆gt;50 years respectively,the differences had statistical significance.Conclusion The HPV infection rate is 23.94% in Bao′an district.The most prevalent HPV genotypes are HPV 52,16,58,43.Women in age 15-20 years old have a higher infection rate.