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可溶性转铁蛋白受体检测对非成年人缺铁性贫血的诊断价值 被引量:4

Diagnostic value of soluble transferrin receptor detection in non-adult ion deficiency anemia
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摘要 目的探讨可溶性转铁蛋白受体(sTfR)对非成年人缺铁性贫血(IDA)的诊断价值及其与慢性病贫血(ACD)的鉴别诊断价值。方法 IDA组26例,男12例,女14例,年龄1月至15.5岁;ACD组33例,男17例,女16例,年龄2月至14.0岁;对照组30例,男15例,女15例,年龄1月至15.5岁。sTfR、铁蛋白(SF)检测方法为免疫比浊法,血清铁(SI)为亚铁嗪比色法。结果各组患儿的性别比例、年龄无显著性差异;ACD组的SI均值介于IDA组和对照组之间;IDA组的SF显著低于ACD组(P<0.001)和对照组(P<0.001),而sTfR显著高于ACD组(P<0.001)和对照组(P<0.001)。sTfR鉴别诊断IDA和ACD的截值为3.56mg/L,其敏感性、特异性、阴性预测值、阳性预测值、准确性分别为95.12%、93.92%、94.11%、97.53%、95.50%。结论sTfR对IDA具有较高的敏感性及特异性,有助于诊断IDA及鉴别诊断ACD。 Objective To investigate the diagnostic value of the soluble transferrin receptor (sTfR)in non-adult iron deficiency anemia (IDA)and its differential diagnostic value between IDA and anemia of chronic disease(ACD).Methods 26 cases in the IDA group involved 12 males and 14 females,aged 1 month to 15.5 years;33 cases in the ACD group involved 17 males and 16 females, aged 2 months to 14.0 years;30 cases in the normal control group involved 15 males and 15 females,aged 1 month to 15.5 years. Serum sTfR and ferritin (SF)were detected by the immunonehelomitery,serum iron (SI)was detected by Ferrous Oxazine colori-metric method.Results The gender and age had no statistically significant difference among 3 groups;the SI mean value in the ACD group located between the IDA group′s and the normal control group′s;the SF mean value of the IDA group was significantly lower than that of ACD group (P 〈0.001)and that of control group (P 〈0.001),while the sTfR mean value of IDA group was significantly higher than that of the ACD group (P 〈0.001)and that of the normal control group (P 〈0.001).The best cutoff of sTfR for the differential diagnosis between IDA and ACD was 3.56 mg/L,its sensitivity,specificity,negative predictive value,posi-tive predictive value and accuracy were 95.12%,93.92%,94.11%,97.53% and 95.50% respectively.Conclusion sTfR has higher sensitivity and specificity for IDA and is conducive to diagnose IDA and differentially diagnose ACD.
出处 《国际检验医学杂志》 CAS 2014年第14期1885-1886,共2页 International Journal of Laboratory Medicine
关键词 非成年人 受体 转铁蛋白 诊断 缺铁性贫血 慢性病贫血 non-adult transferring receptor diagnosis iron deficiency anemia anemia of chronic disease
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参考文献8

  • 1Chang S,Wang L,Wang Y,et al. Iron-deficiency anemia in infancy and social emotional development in preschool-aged Chinese children[J]. Pediatrics,2011,127(4) :927-933.
  • 2Skikne BS, Punnonen K, Caldron PH, et al, Improved differential diagnosis of anemia of chronic disease and iron deficiency anemia: a prospective multicenter evaluation of soluble transferrin receptor and the sTfR/log ferritin index[J]. Am J Hematol,2011,86(11) : 923- 927.
  • 3蒋玉莲,莫丽亚.可溶性转铁蛋白受体的研究进展[J].实用预防医学,2011,18(3):578-580. 被引量:5
  • 4无.儿童缺铁和缺铁性贫血防治建议[J].中华儿科杂志,2008,46(7):502-504. 被引量:157
  • 5李蓉生.慢性病贫血[J].中华检验医学杂志,2011,34(2):190-192. 被引量:9
  • 6Speeckaert MM, Speeckaert R, Delanghe JR. Biological and clinical aspects of soluble transferrin receptor[J]. Crit Rev Clin Lab Sci, 2010,47(5/6) :213 -228.
  • 7Huang SC, Yang YJ,Cheng CN, et al. The etiology and treatment outcome of iron deficiency and iron deficiency anemia in children [J]. J Pediatr Hematol Oncol,2010,32(4):282-285.
  • 8Kemmer TM,Novotny R, Ah Ping I. Iron deficiency and anemia: disparity exists between children in American Samoa and children living within the US[J]. Eur J Clin Nutr,2008,62(6) :754- 760.

二级参考文献58

  • 1中国儿童铁缺乏症流行病学调查协作组.中国7个月~7岁儿童铁缺乏症流行病学的调查研究[J].中华儿科杂志,2004,42(12):886-891. 被引量:230
  • 2Kazal LA. Prevention of iron deficiency in infants and toddlers. Am Faro Physician, 2002,66 : 1217-1224.
  • 3Looker AC, Cogswell ME, Gunter EW. Iron deficiency-United States 1999-2000. MMWR, 2002,51:897-899.
  • 4WHO/UNICEF/UNU. Iron deficiency anemia: assessment, prevention and control-a guide for program managers. Geneva, 2001 : 1-132.
  • 5Grantham-McGregnr S, Ani C. A review of studies on the effect of iron deficiency on cognitive development in children. J Nutr, 2001,131 (Suppl) :649S-668S.
  • 6Lozoff B, Jimenez E, Hagen J, et al. Poorer behavioral and developmental outcome more than 10 years after treatment for iron deficiency in infancy. Pediatrics, 2000,105 :e51-e61.
  • 7Lozoff B, Beard J, Connor J, et al. Long-lasting neural and behavioral effects of iron deficiency in infancy. Nutr Rev,2006,64 (5Pt2) :S34-S91.
  • 8McCanne JC, Ames BN. An overview of evidence for a causal relation between iron deficiency during development and deficits in cognitive or behavioral function. Am J Clin Nutr, 2007,85:931- 945.
  • 9Sachdev H, Gera T, Nestel P. Effect of ire supplementation on mental and motor development in children: systematic review of randomized controlled trials. Pub Health Nutr,2005 ,8 :117-132.
  • 10廖清奎.小儿IDA诊断标准和建议[J].中华儿科杂志,1989,27:159-159.

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