肥胖结肠癌患者血清脂肪因子与细胞因子水平的相关性分析

Correlation analysis of serum adipokines and cytokines levels in obese patients with colon cancer

目的探讨肥胖结肠癌患者血清脂肪因子与细胞因子水平相关性分析。方法选择2011年1至2013年6月收治的肥胖结肠癌患者53例为观察组,同时选择非肥胖的结肠癌患者51例为对照组,采用Duke分期标准对患者进行分期。对两组患者的TNF-α、IGF-1、VEGF及脂肪因子水平进行测定。结果观察组A^B期及C^D期与对照组同期相比,IGF-1较对照组同期均出现显著性升高(P<0.05)。观察组内C^D期较A^B期TNF-α、IGF-1、VEGF显著升高(P<0.05),对照组C^D期较A^B期TNF-α、VEGF显著升高(P<0.05)。观察组A^B期与对照组同期相比,内脂素、瘦素较对照组同期均出现显著性升高(P<0.05),C^D期与对照组同期相比,内脂素、抵抗素、瘦素较对照组同期均出现显著性升高(P<0.05)。内脂素与IGF-1、VEGF呈显著正相关(P<0.05),抵抗素与IGF-1呈显著正相关(P<0.05),瘦素与TNF-α、IGF-1、VEGF呈显著正相关(P<0.05)。结论肥胖结肠癌存在明显的脂代谢及细胞因子紊乱,其水平紊乱可能促进结肠癌进展。

Objective To explore the correlation between serum adipokines and cytokines levels in obese patients with colon cancer.Methods 53 patients with obese colon cancer treated in our hospital from January 2011 to June 2013 were selected as the observation group and at the same time 51 cases of non-obese colon cancer were selected as the control group.TNF-α,IGF-1,VEGF and adipokines levels were measured in the two groups.Results The IGF-1 level in the stage A-B and the stage C-D of the ob-servation group was significantly increased compared with the same stages of the control group （P 〈0.05）.The TNF-α,IGF-1 and VEGF levels in the stage C-D of the observation group were significantly higher than those in the stage A-B （P 〈0.05 ）,the TNF-αand VEGF levels in the stage C-D of the control group were significantly increased compared with the stage A-B （P 〈0.05）.The visfatin and leptin levels in the stage A-B of the observation group were significantly increased compared with the same stages of the control group （P 〈0.05）,the visfatin,resistin and leptin levels in the stage stage C-D of the observation group were significantly increased compared with the same stages of the control group （P 〈0.05）.Visfatin was positively correlated with IGF-1 and VEGF （P 〈0.05）,resistin was positively correlated with IGF-1 （P 〈0.05 ）,leptin was positively correlated with TNF-α, IGF-1 and VEGF （P 〈0.05）.Conclusion Obvious lipid metabolism and cellular cytokines disorders exist in obese colon cancer, their disorder level could promote the progression of colon cancer.