1Strieter ER,and Korasick DA. Unraveling the complexity of ubiq- uitin signaling[J]. ACS Chcm Biol,2012,7(1) :52-63.
2Groll M, Ditzel L, Lowe J, et al. Structure of 20S proteasome from yeast at 2.4 A resolution[J]. Nature,1997,386(6624):463- 471.
3Tanaka K. The proteasome: from basic mechanisms to emerging roles[J]. Keio J Med,2013,62(1) : 1-12.
4Rock KL, York IA, Saric T, et al. Protein degradation and the gen- eration of MHC class I-presented peptides[J]. Adv Immunol, 2002,80(1) 1-70.
5Basler M, Kirk C J, Groettrup M. The immunoproteasome in anti- gen processing and other immunological funetions[J]. Curr Opin Immunol, 2013,25 (1) : 74-80.
6Akiyama K, Yokota K, Kagawa S, et al. cDNA cloning and inter feron gamma down-regulation of proteasomal suhunits X and Y [J]. Science, 1994,265(5176) : 1231-1234.
7Aki M, Shimbara N, Takashina M, et al. Interferon-gamma in- duces different subunit organizations and functional diversity of proteasomes[J]. J Biochem, 1994,115(2) 257- 269.
8Kincaid EZ, Che J W, York I, et al. Mice completely lacking immu- noproteasomes show major changes in antigen presentation[J]. Nat Immunol, 2012,13(2) : 129-135.
9Huber EM,Basler M,Schwab R,et al. Immuno and constitutive proteasome crystal structures reveal differences in substrate and inhibitor speeifieity[J]. Cell,2012,148(4) :727-738.
10Kalim KW, Basler M, Kirk CJ, et al. Immunoproteasome subunit LMP7 deficiency and inhibition suppresses Thl and Thl7 but en- hances regulatory T cell differentiation[J]. J Immunol, 2012,189 (8) :4182- 4193.
4Salomonsson S, Rozell BL, Heimburger M, et al. Minor salivary, gland immunohistology in the diagnosis of primal, Sjogren's syndrome [ J]. J Oral Pathol Med, 2009, 38 (3) :282-288.
5Feist E, Kuckelkom U, Dorner T, et al. Autoantibodies in primary Sjogren's syndrome are directed against proteasomal subunits of the alpha and beta type [ J!. Arthritis Rheum, 1999, 42(4) :697-702.
6Egerer K, Kuckelkorn U, Rudolph PE, et al. Circulating proteasomes are markers of cell damage and immunologic ac- tivity in autoimmune diseases [J]. J Rhenmatol, 2002, 29 (10) :2045-2052.
7Hjelmervik TO, Petersen K, Jonassen I, et al. Gene ex-pression profiling of minor salivary glands clearly distingui- shes primary Sjogren's syndrome patients from healthy control subjects [ J ]. Arthritis Rheum, 2005, 52 ( 5 ) : 1534-1544.
8Morawietz L, Martinez-Gamboa L, Scheffler S, et al. Ex- pression of proteasomal immunosubunit betali is dysregulat- ed in inflammatory infiltrates of minor salivary glands in Sjogren's syndrome [ J ] . J Rheumatol, 2009, 36 (12) : 2694 -2703.
9Egerer T, Martinez-Gamboa L, Dankof A, et al. Tissue- specific up-regulation of the proteasome subunit betaSi (LMP7) in Sjogren's syndrome [ J ]. Arthritis Rheum, 2006, 54(5) :1501-1508.
10Krause S, Kuekelkorn U, Dimmer T, et al. Immunoprotea- some subunit LMP2 expression is deregulated in Sjtigren's syndrome but not in other autoimmune disorders [ J]. Ann Rheum Dis, 2006, 65 ( 8 ) : 1021-1027.
