基于碱基间隔距离模型的多瘤病毒系统发育关系分析

The Phylogenetic Analysis of Polyomavirus Based on the Inter-Nucleotide Distance Model

DNA序列的碱基间隔距离分析方法可以对完全基因组序列进行较好地分析,但是对短基因序列分析的效果不佳。因此,在碱基间隔距离的基础上,提出了一种改进的DNA序列碱基间隔距离模型,并结合欧式距离,构建了70种多瘤病毒基因组的系统发育树。通过将所得系统发育树的拓扑结构与已有文献中的结果进行对比与分析,发现所获得的结果同传统方法计算的结果基本一致,验证了所提方法的有效性。

The DNA sequence inter-nucleotide distance analysis method can better analyze the complete genome sequence, but it is not ideal for short genome sequence. Therefore based on inter-nucleotide distance, proposes an improved DNA sequence inter-nucleotide distance model, and combined with Euclidean distance, constructs phylogenetic tree of 70 kinds of polyoma virus genome. Through the comparison of topological structure of the obtained phylogenetic tree with results in the existing literature, finds that the obtained results are basically the same with the results computed by traditional method, and verifies the effectiveness of the proposed method.