社区中重度阿尔茨海默病性痴呆患者的综合治疗分析

Analysis of the Comprehensive Treatment for Patients with Severe Dementia in Alzheimer's Disease in Community

目的分析社区中重度阿尔茨海默病性痴呆患者治疗效果。方法对13例筛选出的社区中重度阿尔茨海默病性痴呆患者进行综合治疗,在综合治疗前及治疗后的3个月、6个月分别用修正长谷川痴呆量表、日常生活活动能力评定量表、简明蒙特利尔认知评估量表等进行测评,比较治疗效果。结果日常生活能力量表治疗6个月后为(25.37±4.67),差异有统计学意义,P<0.05;MoCA量表仅命名、语言、定向力三个方面治疗评分较治疗前有所升高,分别为(2.20±0.71)、(1.27±0.41)、(3.89±0.91),差异有统计学意义,P<0.05,其他的四个方面者及HDS-R治疗后的评分与治疗前差异无统计学意义,P>0.05。结论阿尔茨海默病性痴呆临床治疗很难取得令人满意的效果,重在早期预防及仅有轻度认知功能障碍阶段开展干预。

Objective To analyze the treatment effect of patients with severe dementia in Alzheimer＇s disease in community.Methods 13 cases of patients with severe dementia in Alzheime＇s disease in community were selected and given the comprehensive treatment. The revised Hasegawa Dementia Scale（HDS-R）, Activity of Daily Living Scale（ADL） and Concise Montreal cognitive assessment scale（MoCA） were used to evaluate and the efficacy of the patients before treatment and at 3, 6 months after treatment was compared, respectively. Results After 6 months of treatment, the Activity of Daily Living Scale was 25.37±4.67, the difference was statistically significant compared with that before treatment, P〈0.05; in MoCA scale, only the score of the three aspects of name, language, directional force was higher than that of before treatment, respectively, and which was 2.20 ±0.71, 1.27±0.41,3.89 ±0.91, respectively, the differences were statistically significant, P 0.05; the difference in scores of other four aspects and HDS-R after treatment were not significant as compared with those before treatment, P〉0.05. Conclusion The clinical treatment of dementia in Alzheimer＇s disease is very difficult to obtain a satisfactory effect, and more attention should be paid to early prevention and the intervention should be carried on at the stage of mild cognitive impairment.