氯沙坦与培哚普利联用对老年高血压左室肥厚及血浆纤维蛋白原的影响

The Effect of Losartan Combined with Perindopril on Elderly Hypertensive Left Ventricular Hypertrophy and Plasma Fibrinogen

目的探讨氯沙坦联合培哚普利治疗老年高血压对左室肥厚及血浆纤维蛋白原的影响。方法回顾性分析该院2012年5月—2013年5月收治的90例老年高血压合并左室肥厚患者的资料,按照随机、对照、双盲原则将患者分为观察组及对照组,各45例,两组患者均应用培哚普利治疗,观察组患者加用氯沙坦,患者治疗前后均行彩色多普勒超声心动图检查和血浆纤维蛋白原检查,比较两组患者治疗前后左室肥厚相关指标变化及血浆纤维蛋白原含量变化。结果观察组患者左室肥厚IVST、PWT、LVDd改善明显优于对照组,比较差异有统计学意义(P<0.05);观察组患者血浆纤维蛋白原下降明显,与对照组患者比较差异有统计学意义(P<0.05)。结论氯沙坦联合培哚普利治疗老年高血压能逆转患者左室肥厚并降低血浆纤维蛋白原,效果满意,值得在临床推广。

Objective To investigate the effect of losartan combined with perindopril on left ventricular hypertrophy and plasma fibrinogen of patients with senile hypertension. Methods The data of 90 cases of patients with senile hypertension complicated by left ventricular hypertrophy admitted in our hospital from May, 2012 to May, 2013 were divided into observation group and control group with 45 cases in each according to the randomized, controlled, double-blind principles. Both groups were given perindopril for treatment; in addition, the observation group were given losartan for treatment. Color Doppler echocardiography and plasma fibrinogen detection were performed in the patients before and after the treatment. And the changes of indexes related to left ventricular hypertrophy before and after treatment and plasma fibrinogen levels were compared between the two groups. Results The improvement in left ventricular hypertrophy IVST, PWT, LVDd of the observation group was obviously better than that of the control group, the difference was statistically significant（P〈0.05）; compared with the control group, the plasma fibrinogen of the observation group decreased significantly, the difference was statistically significant（P 0.05）. Conclusion Losartan combined with perindopril for patients with senile hypertension can reverse left ventricular hypertrophy and reduce plasma fibrinogen with satisfactory effect, and it is worthy of clinical promotion.