胸腺五肽联合替比夫定治疗慢性乙型肝炎的疗效

Analysis of Therapeutic Effect of Thymopentin Compined with LdT in Treating Chronic HBV

目的研究胸腺五肽联合替比夫定治疗慢性乙型肝炎疗效及患者血清IL-10、IFN-γ水平的变化方法将90例慢性乙型肝炎患者随机分为观察组和对照组,对照组服用替比夫定治疗,观察组在替比夫定治疗的基础上联合用胸腺五肽治疗。疗程均为24周。分别比较两组患者治疗4周、12周、24周时ALT、HBVDNA、IL-10、IFN-γ的变化。结果治疗12周、24周时观察组患者ALT、HBVDNA的复常率明显高于对照组(P<0.05),IFN-γ含量从第4周开始出现明显上升,而IL-10表现为从第4周起持续下降。结论胸腺五肽联合替比夫定治疗慢性乙型肝炎患者近期疗效显著,主要作用机制为抑制HBV复制,改善肝功能和改善慢性乙型肝炎患者血清IFN-γ、IL-10水平失衡,有助于慢性乙型肝炎感染者免疫力的恢复。

Objective To investigate the effect of therapy of chronic hepatitis B and evaluate the changes of interleukin-10（IL - 10） and interferon- γ （IFN - γ） level during the course of TP-5 and LDT therapy in HBV infected patients. Methods 90 chronic hepatitis B（CBH） patients were divided randomly into the observation group and the control group .The 45 patients in the control group were treated with LDT only; the remaining 45 patients in the observation group were treated with TP-5 and LDT. The treatment lasted for 24 weeks in both groups. Variation of ALT,HBVDNA, IL-10,IFN-γ before and after treatment were surveyed respectively at 4th,12th and 24th week in both groups. Results Both at 12th and 24th week, the recovery rate of ALT and HBVDM was significantly higher than those of the control group （p 〈 0.05）, IL - 10 reduced significantly by the 4th ,24th week,but IFIV- γ increased. Conclusion TP-5 and LDT is clinically effective to treat chronic hepatitis B by decreasing the HBV replication and improving the liver function, improving the imbalanced expression of cytokines IL-10 and IFN- γ and ameliorating the immunity of CHB patents.