艾司西酞普兰合并经颅磁刺激治疗首发抑郁症的对照研究

The Control Study on S-citalopram Combined with Repetitive Transcranial Magnetic Stimulation in the Treatment of First-episode Major Depressive Disorder

目的探讨艾司西酞普兰合并经颅磁刺激对首发抑郁症的疗效。方法将80例首次发病的抑郁症患者随机分为观察组和对照组,每组各40例。观察组采用艾司西酞普兰合并经颅磁刺激治疗,而对照组单用艾司西酞普兰治疗,疗程6周,与治疗前及治疗后1,2,4,6周末分别进行汉密顿抑郁量表(HAMD)评定,所获数据经方差分析、t检验和??2检验。结果观察组在治疗的第1,2,4,6周末HAMD量表评分及减分率与对照组比较,差异均有显著性,两组间比较,观察组较对照组下降更显著。两组不良反应差异无显著性。结论艾司西酞普兰合并经颅磁刺激治疗对首发抑郁症患者疗效显著,能缩短疗程。

Objective To investigate the clinical effects of S-citalopram combined with repetitive transcranial mag- netic stimulation（rTMS） on patients with frist-episode major depressive disorder.Methods 80 cases of the first-episode major depressive disorder enrolled 40 cases in observe group（S-citalopram associated with rTMS）,40cases in contrast group（only with S-sitaiopram）and were followed-up of the treatment to 6 weeks. Cinical efficacy was evluated by Hamil- ton Depression Scale（HAMD-17） before and 1,2,4,6week after the treatment, All data use variance analysis t test. Re- sults There was significant difference in total score of reduction rate HAMD after 1,2,4,6 weeks. Between two group de- creased more significantly.There was no significant differece in side effects between two groups.Conclusion S-citalo- pram combined with repetitive transcranial magnetic stimulation（rTMS） on patients has a significant curative effect and can shorten the course of treatment.