胱抑素C在早期糖尿病肾病诊断中的应用

The Elf Inhibition C in the Diagnosis of Early Diabetic Nephropathy

目的探讨血清胱抑素C在早期糖尿病肾病诊断中的意义。方法选取2型糖尿病患者156例,依据尿白蛋白/肌酐比值(ACR)分为3组,检测血肌酐(Scr)、尿素氮(BUN)、尿微量白蛋白/肌酐比值(ACR)、胱抑素C。采用酶法检测Scr、BUN;免疫透射比浊法测定ACR;颗粒增强透射免疫比浊法检测胱抑素C。采用C-G公式计算肾小球滤过率(GFR)。结果早期糖尿病肾病组与单纯糖尿病比较显示血清胱抑素C水平升高(P<0.05);临床糖尿病肾病组血清胱抑素C、Scr、GFR水平与单纯糖尿病肾病组、早期糖尿病肾病组相比有显著性差异(P<0.05)。结论血清胱抑素C是预测早期糖尿病肾病的敏感指标。

Objective To investigate the significance of urinary inhibition C serum in the diagnosis of diabetic ne- phropathy. Methods According to urinary albumin/creatinine ratio （ACR）, choose 156 patients with type 2 diabetes, and divided them into three groups to detect serum creatinine （Scr）, urea nitrogen （BUN）, urine trace albumin/creatinine ratio （ACR）, urinary inhibition C. Using enzymatic detection of Scr, BUN, Immune transmission turbidimetry determination of ACR; Particles reinforced transmission immune turbidimetric method to detect urinary inhibition C. The C- G formula Glomerular filtration rate （GFR） is calculated by the C-G formula. Results Early diabetic nephropathy group compared with pure diabetes showed that urinary inhibition C levels of serum rises （P 〈 0.05）; There are significant difference on clin- ical diabetic nephropathy group （serum inhibition C, Scr, GFR level and simple diabetic nephropathy group, the early dia- betic nephropathy group compared statistically significant （P 〈 0.05）. Conclusion Serum （inhibition C is a sensitive in- dex of predictor of diabetic nephropathy.