Clinical research on treating fracture of middle and lower 1/3 of tibiofibula by electroacupuncture

电针治疗胫腓骨中下1/3骨折的临床研究(英文)

Objective To observe the differences in efficacy on treatment of fractures of the middle and lower 1/3 of the tibiofibula between cribriform splints plus electroacupuncture, warming needle and moxibustion only, and external fixation with traditional splints pius the administration of an herbal formula. Clinical efficacy and the effects on serum bone morphogenic protein -7 （BMP- 7） and endothelin-l（ET-1） were both measured. Method 600 patients with fractures of the middle and lower 1/3 of the tibiofibula were randomly divided into three groups according to andome number table： splint with electroacupuncture （group A}, warm needling moxibustion group （group B） and splint with traditional Chinese medicine herb （Group C）. Cribriform splints with electroacupuncture were used in group A, warming needling therapy were adopted in group B, and traditional splints with external fixation were used along with oral administration of musk bone capsules （麝香接骨胶囊） in group C. Clinical results for the three groups were compared, and ELISA method was used to detect the serum BMP-7 and ET-1 of patients in the three groups before and after treatment. Results Group A was better than group B and group C in terms of clinical healing days and delayed healing status （P〈0.05）. After treatment, group A was also better than the other two groups in the improvement of BMP-7 and ET-1 （P〈0.05）. Conclusion Electroacupuncture treatment with cribriform splints for fractures of the middle and lower 1/3 of the tibiofibula resulted in significantly shorter clinical healing time, and lower incidence of delayed healing compared to warm needling or splints with a traditional Chinese herbal formula. Its mechanism may be associated with greater regulation of serum BMP-7 and ET-1 through electroacupuncture.

目的:观察筛状夹板配合电针、针灸和传统夹板外固定对胫腓骨中下1/3骨折患者的疗效差异和对血清骨形成蛋白-7(Bone Morphogenic Protein 7,BMP-7)、内皮素-1(Endothelin-1,ET-1)的影响。方法:将600例胫腓骨中下1/3骨折患者随机分为夹板加电针组、温针灸组及夹板加中药组,夹板加电针组采用筛状夹板配合电针,温针灸组采用温针灸治疗,夹板加中药组使用传统夹板外固定并服用麝香接骨胶囊,比较各组的临床愈合情况;ELISA方法检测3组患者治疗前后血清BMP-7、ET-1。结果:夹板加电针组在临床愈合天数及延迟愈合情况均优于温针灸组及夹板加中药组(P<0.05)。治疗后夹板加电针组对BMP-7及ET-1的改善均优于其他两组(P<0.05)。结论:电针配合筛状夹板固定治疗胫腓骨中下1/3骨折明显缩短临床愈合时间,降低延迟愈合的发生率,疗效优于筛状夹板配合温针灸或中药,可能与调节血液BMP-7及ET-1有关。