摘要
Objective To investigate the clinical efficacy of acupuncture combined with medicine for AIzheimer＇s disease. Methods Fifty-five patients of Alzheimer＇s disease were randomly divided into two groups in accordance with random number table： the drug group （n=28） was treated with oral donepezil hydrochloride tablets, once a day for 5-10 mg with 10 days as a course of treatment; the combined acupuncture and drug group （n=27） was treated with cranial suture acupuncture combined with donepezil hydrochloride tablets in the above-mentioned way. The cranial suture acupuncture was given once a day for 30 min with 10 days as a course of treatment. Both groups were given treatment for two courses. Mini-mental state examination （MMSE）, Alzheimer＇s disease assessment scale （ADAS-Cog）, activities of daily living scale （Barthel） and electroencephalogram （EEG） were checked before and after treatment, to evaluate the efficacy of each group via integral changes of Barthel. Results MMSE score increased, Barthel index score increased, and ADAS-Cog score decreased in the two groups after treatment （P〈0.05, P〈0.01）, and the efficacy of the combined acupuncture and drug group was more significant （P〈0.01）. The α wave frequency and amplitude and θ wave frequency of EEG increased after treatment in both groups （P〈0.05）, θ wave amplitude decreased （P〈0.01）, and the efficacy of the combined acupuncture and drug group was superior to that of the drug group in terms of EEG improvement （P〈0.05）. The total effective rate of the combined acupuncture and drug group （88.9%, 24/27） was superior to that of drug group （67.9%, 18/28, P〈0.05）. Conclusion The effect of cranial suture acupuncture combined with donepezil hydrochloride tablets for Alzheimer＇s disease is more significant than only medicine therapy.
目的:探讨针刺与药物结合治疗阿尔茨海默病的临床疗效。方法:55例阿尔茨海默病患者随机分为两组,药物组(n=28)给予盐酸多奈哌齐片口服,每次5-10 mg,每天1次口服,10天为1个疗程。针药组(n=27)在口服盐酸多奈哌齐片基础上加用颅针,每日1次,每次30 min,10天为1个疗程。两组均治疗2个疗程。治疗前后进行简易精神状态评价量表(MMSE)、ADAS-Cog认知项目量表、日常生活活动能力量表(Barthel)、脑电图(EEG)的检查,以Barthel积分变化评价两组的疗效。结果:两组治疗前后MMSE评分均升高,Barthel指数评分升高,ADAS-Cog量表评分降低(P<0.05,P<0.01),针药组的疗效更明显(P<0.01)。两组患者治疗后脑电图a波频和波幅、θ波频均增加(均P<0.05),θ波幅降低(均P<0.01),针药组在脑电改善方面均优于药物组(均P<0.05)。两组患者疗效比较,针药组总有效率为88.9%(24/27),优于药物组的67.9%(18/28,P<0.05)。结论:颅针结合盐酸多奈哌齐片治疗阿尔茨海默病疗效优于单纯药物治疗。
