外用重组人粒细胞巨噬细胞刺激因子凝胶剂联合优拓治疗深Ⅱ度烧伤30例疗效分析

Analysis of clinical therapeutic effect of 30 cases of deep thickness burns by topical application of recombinant human granulocyte-macrophage colony-stimulating factor hydro-gel combined with urgotul

目的分析比较外用重组人粒细胞巨噬细胞刺激因子(rhGM-CSF)凝胶剂联合优拓与磺胺嘧啶银乳膏治疗深II度烧伤疗效。方法 60例深II度烧伤患者,随机分成两组,其中rhGM-CSF联合优拓治疗的患者为治疗组,使用磺胺嘧啶银乳膏的患者为对照组,观察创面愈合时间、患者疼痛度及愈合后疤痕增生情况。结果 rhGM-CSF联合优拓组治疗效果明显优于对照组,rhGM-CSF联合优拓治疗组的愈合时间(15.1±2.0)d明显短于对照组(20.7±2.3)d,平均愈合时间提前3~5d;患者疼痛度明显减轻[VAS评分分别是(1.45±0.08)和(3.63±0.14)];1年后随访rhGM-CSF联合优拓治疗组疤痕增生明显较轻。结论rhGM-CSF联合优拓治疗深Ⅱ度烧伤疗效确切。患者愈合时间短、疼痛度减少、愈合后疤痕增生轻。

Objective To compare the effect of creating deep thickness burns by using topical recombinant human granulocyte-macrophage colony-stimulating factor（rhGM^CSF）gels joint urgotul therapy with that by using silver sulfadiazine. Methods Sixty patients with deep thickness burns were randomly divided into 2 groups： treatment group used rhGM-CSF gels joint in patients with urgotul, the control group treated with silver sulfadiazine. Both of them were observed about the wound healing time,the degree of pain and the situation of their scarring. Results The treatment effect of rhGM-CSF gels joint urgotul therapy was better than that of silver sulfadiazine for shorter healing time, with 3 ～ 5 days in advance;obviously lighter pain[the score of VAS is （1.45±0.08）and （3.63±0.14）] and less scarring after one year. Conclusion rhGM-CSF therapy with urgotul on deep thickness burns was effective with shorter healing time,lighter pain and less scarring.