社区获得性肺炎患者PCT、IL-6、CRP检测的临床意义

Clinical significance of serum PCT,IL-6 and CRP in patients with community acquired pneumonia

目的探讨成人社区获得性肺炎(CAP)患者PCT、IL-6、CRP检测的临床意义。方法选择2012年12月-2013年7月住院的成人CAP患者105例作为观察组,同期于体检中心随机抽取33例健康体检者作为对照组,观察组于入院后运用抗生素前、治疗后第3、7天抽取静脉血,对照组于体检当天抽取静脉血,2组均采用电化学发光法测定血清PCT、IL-6浓度,散射比浊法测定血清CRP浓度,比较2组间及观察组治疗前后PCT、IL-6、CRP浓度。结果CAP观察组血清PCT、IL-6、CRP、WBC计数、中性粒细胞百分比测定值均明显高于健康对照组,差异有统计学意义(P<0.05);CAP观察组血清PCT、IL-6、CRP浓度治疗前均明显高于治疗后第3、7天,差异有统计学意义(P<0.05)。结论血清PCT、IL-6和CRP测定对CAP有一定的诊断价值,且可以作为疗效观察的重要指标。

Objective To investigate the clinical significance of serum PCT,IL-6 and CRP in adult patients with com-munity acquired pneumonia（CAP）. Methods 105 patients with CAP who hospitalized during the period of December 2012 to July 2013 were admitted as CAP group. meanwhile,33 normal healthy individuals were taken as control group. Blood samples of CAP group were extracted before using antibiotics and after treatment for 3,7 days,which of the control group were extracted on the day of physical examination. The PCT and IL-6 level of 2 groups were determined by electrochemical luminescence method,and the CRP level was determined by immunity-turbidity method. Results The Serum PCT,IL-6 and CRP levels of the CAP group were significantly higher than the normal control group,the differences were statistically significant（P ﹤ 0. 05）. The serum PCT,IL-6 and CRP levels before treatment were significantly higher than the 3 and 7 days after treatment in CAP group,the differences were statistically significant（P ﹤ 0. 05）. Conclusion The serum PCT,IL-6 and CRP have diagnostic value for the CAP,and may could be as the objective marker for clinical effect observation.