氨基葡萄糖联合玻璃酸钠对膝骨关节炎的治疗作用

The Therapeutic Effect of Glucosamine Combined with Sodium Hyaluronate in the Treatment of Osteoarthritis of the Knee

目的探讨氨基葡萄糖联合玻璃酸钠治疗膝骨关节炎的临床效果。方法选取2010年2月—2012年12月本院治疗的膝骨关节炎患者92例,随机分为治疗组和对照组各46例,其中对照组患者单用玻璃酸钠治疗,治疗组患者采用氨基葡萄糖联合玻璃酸钠治疗,比较两组患者的临床效果、膝关节肿胀和疼痛消失时间及治疗前后视觉模拟(VAS)评分和膝关节关节镜(Lysholm)评分情况。结果治疗后治疗组患者的总有效率91.30%(42/46),对照组患者的总有效率76.09%(35/46),两组比较差异有统计学意义(P<0.05)。治疗组患者膝关节肿胀消失时间、疼痛消失时间均短于对照组患者,差异有统计学意义(P<0.05)。治疗后治疗组患者的VAS评分低于对照组患者,Lysholm评分高于对照组患者,差异有统计学意义(P<0.05)。结论氨基葡萄糖联合玻璃酸钠治疗膝骨关节炎,膝关节肿胀疼痛等临床症状得到快速改善,膝关节功能增强,临床效果显著。

Objective To study the clinical effect of glucosamine combined with sodium hyaluronate in the treatment of osteoarthritis of the knee. Methods 92 patients of osteoarthritis of the knee in our hospital from February 2010 to December2012,which were randomly divided into the treatment group and the control group,46 cases in each group. The control group was treated with sodium hyaluronate,the treatment group was treated with glucosamine combined with sodium hyaluronate. The clinical effect,knee swelling and pain VAS scores before and after treatment,and the time and circumstances Lysholm score of the two groups were compared. Results After treatment,the total effective rate of the treatment group was 91. 30%（ 42 /46）,which was higher than 76. 09%（ 35 /46） of the control group,the difference was statistically significant（ P〈0. 05）. The knee swelling and pain disappeared time period in the treatment group was shorter than the control group,the difference was statistically significant（ P〈0. 05）. After treatment,the VAS score in the treatment was lower than the control group,Lysholm score was higher than the control group,the differences were statistically significant（ P〈0. 05）. Conclusion Glucosamine combined with sodium hyaluronate in the treatment of osteoarthritis of the knee,the knee swelling,pain and other symptoms have achieved rapidly improvement,and the knee function has improved,the clinical effect is significant.