α-catulin和E-cadherin在舌鳞状细胞癌组织中的表达及其临床意义

Expressions of α-catulin and E-cadherin in tongue squamous cell carcinoma tissue and clinical significance

目的:观察舌鳞状细胞癌(TSCC)组织中α-catulin蛋白和上皮-钙黏蛋白(E-cadherin)的表达情况,探讨两者表达与TSCC发生、发展的关系。方法:采用免疫组织化学SP法检测55例TSCC组织和10例正常舌黏膜组织中α-catulin和E-cadherin蛋白的表达,并分析两者在TSCC组织中的表达情况与患者临床病理特征的关系以及两者在TSCC组织中表达的相关性。结果:TSCC和正常舌黏膜组织中α-catulin蛋白阳性表达率分别为69.09%和20.00%,二者比较差异有统计学意义(P<0.01);α-catulin的表达与TSCC的组织学分化程度、临床分期和颈淋巴结转移均有关联(P<0.05)。在TSCC组织中和正常舌黏膜中E-cadherin蛋白阳性表达率分别为38.18%和80.00%,二者比较差异有统计学意义(P<0.01);E-cadherin蛋白阳性表达率与TSCC的临床分期和颈淋巴结转移有关联(P<0.05)。Spearman等级相关分析,TSCC组织中α-catulin与E-cadherin蛋白表达呈负相关关系(r=-0.466,P<0.01)。结论:α-catulin和E-cadherin可能与TSCC的发生和发展密切相关,有望成为临床判断TSCC恶性程度和预后的指标。

Objective To observe the expressions ofα-catulin and E-cadherin in tongue squamous cell carcinoma（TSCC）tissue,and to explore their relationship with the occurrence and development of TSCC.Methods The expressions ofα-catulin and E-cadherin in 55 cases of TSCC tissue and 10 cases of normal tongue tissue were examined by immunohistochemistry SP method. The relationship between the expressions and the clinicopathological characteristics and the relevance of the expressions ofα-catulin and E-cadherin in TSCC tissue were analyzed.Results The positive expression rates ofα-catulin in TSCC tissue and normal tongue tissue were 69.09% and 20.00%,respectively,and there was difference between them（P〈0.01）.The expression ofα-catulin was correlated to the histological differentiation,clinical stage and lymph node metastases of TSCC（P〈0.05）.The positive expression rates of E-cadherin in TSCC tissue and normal tongue tissue were 38.18% and 80.00%,respectively,and there was significant difference between them（P 0.01）.The expression of E-cadherin was correlated to the clinical stage and lymph node metastases of TSCC（P〈0.05）.There was a negative correlation between the expressions ofα-catulin and E-cadherin in TSCC tissue（r=-0.466,P〈0.01）.Conclusion The expressions ofα-catulin and E-cadherin may be associated with the occurrence and development of TSCC,and they could be used as the parameters which predict the malignant degree and prognosis of TSCC.