MODS患儿血清磷酯酶A_2的变化及意义

The role and significance of phospholipase A_2 in children with multiple organ dysfunction syndrome

目的 :探讨磷酯酶A2 (PLA2 )在多脏器功能障碍综合征 (MODS)患儿中的作用及意义。方法 :结合危重病例评分 ,采用ELISA法检测 2 6例MODS患儿血清PLA2 含量 ,并与健康体检儿童 2 0例对照。结果 :多脏器功能障碍综合征患儿血清PLA2 含量明显高于正常对照组 ,P <0 .0 1,并与危重病例评分成正相关。结论 :PLA2 参与MODS的病理生理过程 ,与危重病的病情有关 ,并可作为早期预警多脏器功能障碍综合征的实验参数。

Objective:To investigate the action and significance of phospholipase A 2 (PlA 2) in the pejorative process of Children with multiple organ dysfunction syndrome(MODS). Methods: Combined with the critical care scores, Serum concentrations of PLA 2 were determined 26 children with MODS and 20 healthy children by ELISA method. Results: Serum concentrations of PLA 2 in MODS were significantly higher than these in healthy children (P>0.01), and the serum PLA 2 level correlated directly with the critical care scores. Conclusion: PLA 2 are involved in the Pathophysiologic process of MODS. PLA 2 are a laboratory parameter to alarm to the development of MODS.