枸橼酸钠雷尼替丁阿莫西林呋喃唑酮短程三联治疗幽门螺杆菌阳性十二指肠溃疡

Short-term Triple Therapy with Ranitidine Bismuth Citrat、 Amoxicillin、 Furazoli done for treat the doudenal ulcer with Helicobacter pylori infection

目的 :探索根除率较高、价廉、安全实用的HP根除方案。方法 :5 6例HP阳性的十二指肠球部溃疡患者进入试验 ,可评价病例 5 0例 ,随机分组 ,A组 2 7例 :枸椽酸铋雷尼替丁 35 0mg +阿莫西林 10 0 0mg +呋喃唑酮 10 0mg每天 2次 ,疗程 7d。B组 2 3例 :奥美拉唑 2 0mg +克拉霉素 5 0 0mg +阿莫西林 10 0 0mg每天 2次 ,疗程 7d。观察记录HP根除情况、溃疡愈合情况、临床症状改善情况及不良反应。结果 :A、B二组HP根除率分别为 85 .2 %、82 .5 % ,溃疡愈合率分别为 81.5 %、82 .5 % ,三日腹痛缓解率分别为 70 .4 %、73.4 % ,平均腹痛缓解时间分别为 4 .2 3± 2 .5d、3.95± 1.9d ,各组间差异无显著性 ,P >0 .0 5 ,二组均有轻微不良反应 ,但不影响治疗。A、B二组每例抗HP所需费用分别为 10 2 .2元、35 5 .9元。结论 :以枸椽酸铋雷尼替丁、阿莫西林、呋喃唑酮三联一周方案是一种新的、根除率较高、价廉、安全实用的HP根除方案。

Objective: To explore the optimal vegimens for the eradication of helicobacter pylori(H.Pylori) Methods:56 patient with duodenal ulcer (Du) all were H.pylori positive joined trial and 50 completed cases were divided into 2 groups. Group A (n=27) were treated with triple therapy of ranitidine bismuth citrate (RBC) 350mg+amoxicillin 1000mg+furazolidone 100mg bid for 1 week .Group B (n=23) omeprazole 20mg+ clrarithromgcin 500mg+amoxicillin 1000mg bid for 1 week .Results of H.pylori eradication the thing of ulcer healing,clinical symptoms and side effects were observed and recorded . Results: The H.pylori eradication rates in groups A and B were 85.2%?82.5%. Ulcer healing rates were 81.5%?82.5%,percentage of disappearance of abdominal pain at third days were 70.4%?73.4%, and mean time were 4.23+2.5d?3.95+1.9d. The differences were not singificant statistically (P>0.05). Mild side effects noted in two groups. but they did not interfere treatment .The cost of anti-HP therapy every patient in group A?B were 102.2 and 355.9 (RMB.yuan). Conclusions:The short-term triple therapy of RBC?Amoxicillin ?Furazolidone are highly effective in active duodenal ulcer with H.pylori infection and the new regimens seems to have better tolance ,compliance and lower cost.