老年急性髓细胞白血病患者院内感染分析

Analysis of the hospital infection of elderly patients with acute myeloid leukemia

目的 :总结老年急性髓细胞白血病患者院内感染及治疗情况 ,以期提高治疗水平。方法 :回顾分析 2 7例老年急性髓细胞白血病患者的院内感染发生率、感染部位、危险因素和治疗情况等 ,并与同期 85例非老年患者进行比较。结果 :老年组发生院内感染 2 2例 (81.5 % ) ,高于同期非老年组(5 6例 ,6 5 .9% )。感染部位以呼吸系统多见 (15例 ,6 8.2 % )。危险因素为白细胞减少、化疗和合并症。单纯抗生素治疗有效率 33.3% ,抗生素加辅助治疗有效率 6 1.1% ,二者相比差异有显著性 (P <0 .0 5 )。治疗总有效率为 6 8.2 %。结论 :老年急性髓细胞白血病患者院内感染发生率高于同期非老年组。抗生素加辅助治疗优于单纯抗生素治疗。

Objective: To improve the treatment of the hospital infection of the elderly patients with acute myeloid leukemia. Methods:The data of the hospital infection and treatment of 27 elderly acute leukemic patients were reviewed , including the inciden-ce of nosocomial infection, the most commonly infected site, the risk factors and the overall response rate. Results:The incidence of nosocomial infection was 81.5%. The most commonly infected site was respiratory system (68.2%). The factors of high risk included low WBC (86.4%), chemotherapy (81.8%) and complication (63.6%). The response rate with antibiotics alone and antibiotics combined with supportive therapy was 33.3% and 61.1% respectively (p<0.05). The overall response rate was 68.2%. Conclusions: The incidence of nosocominal infection of elderly acute leukemic patients was higher than non-elderly group in the same period. The combination of antibiotics with supportive therapy was better than antibiotics alone. Control of infection is related to acute leukemic remission.