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New insight into vascular homeostasis and injury-reconstruction 被引量:4

New insight into vascular homeostasis and injury-reconstruction
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摘要 Acquired vascular abnormalities are a pivotal part of the pathophysiology of multiple cardiovascular and metabolic diseases.Complications of various types of vascular pathology,for example,stroke,myocardial infarction and aortic dissection constitute most common causes of disability and deaths worldwide[1].Ageing per se is also associated with significant remodeling of vasculatures that exacerbates concomitant cardiovascular or metabolic diseases[2].Important discoveries in the field of vascular biology have Acquired vascular abnormalities are a pivotal part of the pathophysiology of multiple cardiovascular and metabolic diseases.Complications of various types of vascular pathology,for example,stroke,myocardial infarction and aortic dissection constitute most common causes of disability and deaths worldwide[1].Ageing per se is also associated with significant remodeling of vasculatures that exacerbates concomitant cardiovascular or metabolic diseases[2].Important discoveries in the field of vascular biology
出处 《Science China(Life Sciences)》 SCIE CAS 2014年第8期739-741,共3页 中国科学(生命科学英文版)
基金 supported by the National Natural Science Foundation of China(91339000)
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  • 1World Health Organization. The 10 leading causes of death in the world, 2000 and 2012. 2014, available from http://www.who.intl mediacentre/factsheets/fs310/en/.
  • 2Bachschmid MM, Schildknecht S, Matsui R. Zee R, Haeussler D. Cohen RA. Pimental D, Loo BY. Vascular aging: chronic oxidative stress and impairment of redox signaling-consequences for vascular homeostasis and disease. Ann Med, 2013, 45: 17-36.
  • 3Yu H, Clarke MC, Figg N, Littlewood TD, Bennett MR. Smooth muscle cell apoptosis promotes vessel remodeling and repair via activation of cell migration, proliferation. and collagen synthesis. Arterioscler Thromb Vase Bioi, 2011, 31: 2402-2409.
  • 4Chen Q, Iin M. Yang F, Zhu J. Xiao Q, Zhang L. Matrix metalloproteinases: inflammatory regulators of cell behaviors in vascular formation and remodeling. Mediators Inflarnrn, 2013, 2013: 928315.
  • 5Baker D, Wijshake T, Tchkonia T, LeBrasseur N, Childs B, van de Sluis B, Kirkland I, van Deursen I. Clearance of pl6Ink4a-positive senescent cells delays ageing-associated disorders. Nature, 2011, 479: 232-236.

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