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生长因子Progranulin的结合受体和生物学功能 被引量：4

The Binding Receptors and Biological Function of the Growth Factor Progranulin
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摘要 生长因子颗粒素蛋白前体(progranulin,PGRN)广泛存在于动物和植物组织中.研究证明,哺乳动物的PGRN是一个多功能分子,在组织/器官发育、细胞分化、肿瘤发生发展、炎症应答以及神经退行性疾病中均具有重要的作用.PGRN发挥生物学功能需要和多种结合蛋白相互结合,例如sortilin、Toll样受体9(TLR9)、肿瘤坏死因子受体(TNFR)及分泌性淋巴细胞蛋白酶抑制因子(SLPI)等.本文将对PGRN的结合受体和生物学功能进行综述. The growth factor progranulin （PGRN） is widely expressed in animal and plant tissues.Previous studies showed that mammal＇ s PGRN has multiple functions and plays important roles in theregulation of tissue and organ development, cancer progression, cell differentiation, inflammationresponse and neuronal degeneration. PGRN exerts its function through associating with several bindingproteins, including sortilin, toll-like receptor 9 （TLR9） , tumor necrosis factor receptor （TNFR） andsecretory leukocyte peptidase inhibitor（SLPI）. Here we review the biological significance of PGRN andits associated proteins.
作者 魏凡华 张玉颖 于修平
机构地区 宁夏大学农学院 山东师范大学生命科学学院 山东大学医学院
出处 《中国生物化学与分子生物学报》 CAS CSCD 北大核心 2014年第7期655-659,共5页 Chinese Journal of Biochemistry and Molecular Biology
基金 国家自然科学基金项目(No.81272209)~~
关键词 颗粒素蛋白前体 炎症 肿瘤 发育 结合受体 progranulin inflammation cancer development binding receptors
分类号 R151.2 [医药卫生—营养与食品卫生学]
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参考文献46

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同被引文献49

  • 1肖渝,许正平.颗粒蛋白前体的生理功能及其与肿瘤发生的关系[J].国际肿瘤学杂志,2006,33(12):890-893. 被引量：5
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中国生物化学与分子生物学报
2014年 第7期

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