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Loss of TCR responsiveness during thymic education imprints the 'innate' signature on γδ T cells

Loss of TCR responsiveness during thymic education imprints the 'innate' signature on γδ T cells
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摘要 T cells expressing γδ determinants are considered innate-like and deviate from the classical αβ T cells in many aspects, including the rapid production of lymphokines following the recognition of 'naked' antigens by the invariant T-cell receptor and failure to differentiate in the periphery. T cells expressing γδ determinants are considered innate-like and deviate from the classical αβ T cells in many aspects, including the rapid production of lymphokines following the recognition of 'naked' antigens by the invariant T-cell receptor and failure to differentiate in the periphery.
机构地区 Department of Surgery
出处 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2014年第4期323-325,共3页 中国免疫学杂志(英文版)
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  • 1Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of Iymphokine activities and secreted proteins. J Immuno/1986; 136: 2348-2357.
  • 2Bending D, de la Perla H, Veldhoen M, Phillips JM, Uyttenhove C, Stockinger B et al. Highly purified Th17 cells from BDC2.5NOD mice convert into Thl-like cells in NOD/SCID recipient mice. J Clin Invest 2009; 119: 565-572.
  • 3Martin-Orozco N, ChungY, ChangSH, Wang YH, Dong C. Th 17 cells promote pancreatic inflammation but only induce diabetes efficiently in Iymphopenic hosts after conversion into Th 1 cells. Eur J Immunol 2009; 39: 216-224.
  • 4Zheng W, Flavell RA. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 1997; 89: 587-596.
  • 5Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH. A novel transcription factor, T-bet, directs Thl lineage commitment. Cell 2000; 100: 655-669.
  • 6Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, Lafaille JJ et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-l r: T helper cells. Cell 2006; 126: 1121-1133.
  • 7Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299: 1057-106l.
  • 8Lazarevic V, Glimcher LH. T-bet in disease. Nat ImmunoI2011; 12: 597-606.
  • 9Rankin LC, Groom JR, Chopin M, Herold MJ, Walker JA, Mielke LA et al. The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway. Nat Immunol 20l3; 14: 389-395.
  • 10Sciurne G, Hirahara K, Takahashi H, Laurence A, Villarino AV, Singleton KL et al. Distinct requirements for T-bet in gut innate lymphoid cells. J Exp Med 2012; 209: 2331-2338.

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