Th22细胞及其效应因子IL-22与炎症性皮肤病关系的研究进展

Research progress of Th22 and IL-22 in inflammatory skin disorders

Th22细胞是一种以IL-22为主要效应因子的新型Th细胞亚群,主要参与皮肤的自稳调节和病理状态,在炎症性皮肤病的病理生理过程中发挥重要作用。该文对Th22及其效应因子IL-22与银屑病、特应性皮炎、系统性红斑狼疮、系统性硬化症等炎症性皮肤病的关系作一综述,为有效防治该类疾病提供新的研究思路和药物靶标。

Th22,a new subset of helper T cells,which is char-acterized by the secretion of interleukin-22（IL-22）,could infil-trate to the epidermis in individuals with inflammatory skin disor-ders.This article introduces the action of Th22 and IL-22 in in-flammatory skin diseases,including psoriasis,atopic dermatitis, systemic lupus erythematosus,systemic sclerosis,aiming at re-vealing the role of Th22 and IL-22 in these diseases,which would not only provide some novel targets of drugs for inflamma-tory skin diseases,but also promote the researches on the pre-vention and treatment of these diseases.