新型喹啉类化合物ZJ5337的生物活性

Biological activity of a novel quinoline compound ZJ5337

ZJ5337（碳酸苄酯-2，3，8-三甲基-6-七氟异丙基-4-喹啉酯）是浙江省化工研究院有限公司创制的一种新型喹啉类杀菌剂。测定了ZJ5337在离体条件下对稻瘟病菌的抑菌效果以及在温室及田间对水稻稻瘟病和黄瓜白粉病的防治效果。在离体条件下，10～20 mg/L的ZJ5337对稻瘟病菌附着孢的形成有显著抑制作用。温室盆栽试验结果表明：在50～100 mg/L剂量下，ZJ5337对水稻稻瘟病和黄瓜白粉病的防效均在80％以上，持效期为15 d 左右；其在黄瓜植株根部和叶片之间以及叶片与叶片之间内吸输导性差；叶面喷雾1～3h 内降雨能明显降低药剂防效，但4h 后降雨对其防效无显著影响。田间试验结果表明，采用2．5％的 ZJ5337乳油在有效成分质量浓度为300～500 mg/L下，对水稻稻瘟病的防效为66％～91％，且对水稻安全。

The antifungal activity and efficacy of a novel quinoline compound ZJ5337 synthesized by Zhejiang Chemical Industry Institute Co. Ltd. was evaluated. In vitro, ZJ5337 at 10 -20 mg/L showed high inhibition activity against the appressorium formation of Magnaporthe grisea. Greenhouse experiments showed that ZJ5337 at 50 -100 mg/L exhibited high activity against the diseases caused by M. grisea and Sphaerotheca fuliginea with the efficacy greater than 80%. In addition, the duration of ZJ5337 was up to 15 days. ZJ5337 was unable to be transferred effectively between root and leaf, and among leaves of cucumber. The rain-wash test showed that rain-wash had significant impact on the efficacy of ZJ5337 within three hours, but not after 4 hours of the compound application. Field trials showed that 300-500 mg/L 2. 5%ZJ5337 EC efficacy of 66% -91% against M. grisea and did not show any phytotoxic to the rice tested.