摘要
目的:研究参芪益元颗粒对戊巴比妥钠所致小鼠学习记忆障碍的影响。方法:腹腔注射戊巴比妥钠(15 mg/kg)以复制小鼠学习记忆障碍模型。50只KM小鼠随机均分为正常对照(等容生理盐水)组、模型(等容生理盐水)组、健脑补肾丸(2.00 g/kg)组与参芪益元颗粒高、低剂量(1.76、0.88 g/kg)组。采用Y型迷宫法测定小鼠正确反应次数;测定小鼠血清超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量。结果:与正常对照组比较,模型组小鼠正确反应次数减少,SOD活性减弱,MDA含量增加,差异有统计学意义(P<0.01);与模型组比较,参芪益元颗粒高、低剂量组小鼠正确反应次数增加,SOD活性增强,MDA含量减少,差异有统计学意义(P<0.01)。结论:参芪益元颗粒对戊巴比妥钠所致小鼠学习记忆障碍具有改善作用。
OBJECTIVE: To study the effects of Shenqi yiyuan granules on learning and memory impairment in mice induced by sodium pentobarbital. METHODS: Learning and memory impairment model was induced by intraperitoneal injection of sodium pentobarbital (15 mg/kg). 50 KM mice were randomly divided into normal control group (constant volume of normal saline), model group (constant volume of normal saline), Jiannao bushen pills group (2.00 g/kg) and Shenqi yiyuan granules high-dose and low-dose groups (1.76, 0.88 g/kg). The average achievement of correct response was observed by the method of the Y-maze test, the activities of SOD and content of MDA in serum were detected. RESULTS: Compared with normal control group, average achievement of correct response were decreased in model group, meanwhile, the activities of SOD was decreased, and content of MDA was increased; there was statistical significance (P〈0.01). Compared with model group, average achievement of correct response were increased in Shenqi yiyuan granules high-dose and low-dose groups; meanwhile, the activities of SOD was increased, and content of MDA was decreased; there was statistical significance(P〈0.01). CONCLUSIONS: The learning and memory impairment of mice induced by sodium pentobarbital can be improved by Shenqi yiyuan granules.
出处
《中国药房》
CAS
CSCD
2014年第31期2893-2895,共3页
China Pharmacy
关键词
参芪益元颗粒
戊巴比妥钠
学习记忆障碍
Y型迷宫法
Shenqi yiyuan granules
Sodium pentobarbital
Learning and memory impairment
Y-maze test