摘要
目的：探讨中药注射剂致不良反应（ADR）发生的成因和特点，为临床合理用药提供参考。方法：对我院2003—2012年上报的209例中药注射剂ADR报告进行统计分析。结果：209例患者中有63例〉70-80岁患者发生ADR，占30．14％；最易引发ADR的药品为心脑血管疾病、呼吸系统疾病以及抗肿瘤的中药注射剂；ADR损害类型主要为皮肤及附件损害，共98例，占46．89％；新的一般ADR65例，新的严重ADR2例。结论：中药注射剂致ADR与用药人群、患者体质、用药剂量、溶媒选择、联合用药、静脉滴速等有关。临床应加强辨证论治、合理用药，以减少ADR的重复发生。
OBJECTIVE：To study the cause and characteristics ADR induced by TCM, and to provide reference for rational use of drugs in the clinic. METHODS： 209 ADR reports induced by TCM injection reported by our hospital during 2003-2012 were analyzed statistically. RESULTS： Among 209 patients, 63 cases aged 70 to 80 years suffered from ADR, accounting for 30.14%; ADR were easily induced by TCM injection as TCM injection for cardiovascular disease, respiratory disease and tumor. ADR main- ly manifested as lesion of skin and its appendants （98 cases, 46.89% ）. Additionally, there were 65 cases of new ADR and 2 cases of new severe ADR. CONCLUSIONS： ADR induced by TCM injection is correlated with medicootion group, the constitution of the patients, drug dosage, solvent selection, drug combination, intravenous drip speed, etc. Great importance should be attached to syndrome differentiation treatment and rational drug use to reduce the repeated occurrence of ADR.
出处
《中国药房》
CAS
CSCD
2014年第31期2949-2951,共3页
China Pharmacy
基金
国家中医药管理局临床药学重点专科项目(No.ZP0101YX001)
