蒙脱石散剂保留灌肠联合口服锌制剂治疗小儿轮状病毒性肠炎疗效观察

目的观察蒙脱石散剂保留灌肠联合口服锌制剂治疗小儿轮状病毒性肠炎的临床效果。方法将梅州市妇幼保健院收治的200例轮状病毒性肠炎患儿按照随机数字表法均分成观察组和对照组(n=100)。对照组患儿采用常规治疗;观察组患儿在常规基础治疗上加用蒙脱石散剂保留灌肠联合口服锌制剂治疗;对2组患儿的起效时间和腹泻时间以及治愈时间等进行比较和分析。结果观察组在起效时间和腹泻时间以及治愈时间明显优于对照组。观察组显效64例,占64.0%;有效34例,占34.0%;无效2例,占2.0%;治疗有效率为98.0%。对照组显效50例,占50.0%;有效32例,占32.0%;无效18例,占18.0%;治疗有效率为82.0%。2组患儿治疗有效率比较,差异有统计学意义(P<0.05)。结论在临床上,对轮状病毒性肠炎住院患儿采用蒙脱石散剂保留灌肠联合口服锌制剂治疗,效果显著,操作简单,安全方便。

Objective To analyze the clinical effect of smecta retention enema therapy combined with oral zinc preparations in pediatric patients hospitalized with rotavirus enteritis. Methods In the hospital, 200 patients grouped according to the random number table were divided into observation group and control group （n=100）;Control group used conventional treatment;Observation group using smecta retention enema therapy combined with oral zinc preparations basis on treatment on regular treatment;Onset time and duration of diarrhea and healing time in two groups of patients were compared and analyzed. Results The onset time and duration of diarrhea and healing time in observation group were significantly better than the control group, in the observation group：64 cases were markedly, accounting for 64.0%;Effective 34 cases, accounting for 34.0%;2 cases, accounting for 2.0%;Treatment effective rate of 98.0%. Control group：50 cases markedly, accounting for 50.0%;Effective 32 cases, accounting for 32.0%;Ineffective in 18 cases, accounting for 18.0%;Therapeutic efficacy was 82.0%. Efficiency in two groups had significant difference （P〈0.05）. Conclusion For hospitalized children with rotavirus enteritis, using mecta retention enema combined with oral zinc preparations for treatment, the effect is significant,simple, safe and convenient.