附子提取物的大鼠生殖毒性研究

Research of reproductive toxicity of mice by extractive of monkshood

目的探讨附子提取物对雌性大鼠生殖毒性的影响。方法附子提取物给大鼠连续灌胃30 d,考察脏器指数、动情期观察、生殖激素含量变化。结果附子提取物造成雌性大鼠动情周期紊乱,脏器指数明显下降,性激素:卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、孕酮(P)含量较阴性对照组均显著下降。结论附子提取物的生殖毒性作用可能与FSH、LH、E2、P含量下降有关,提示提高性激素水平,可有助于降低附子提取物的生殖毒性。

Objective To investigate the influence of extractive of monkshood on the reproductive toxicity of female mice. Methods Gavages to mice was applied continuously for 30 days with extractive of monkshood. The organ index, estrus cycle, and change of reproductive hormone were investigated. Results The extractive of monkshood caused disorders of estrous cycle and obvious decline of visceral index. Contents of sex hormones, such as follicle-stimulating hormone （FSH）, luteinizing hormone （LH）, estradiol （E2）, and progesterone （P） were significantly decreased compared with negative control group. Conclusion The reproductive toxicity of extractive of monkshood may have relation with decreased contents of FSH, LH, E2, and P. Increasing the level of sex hormone can be helpful in decreasing the reproductive toxicity of extractive of monkshood.