摘要
目的观察多发性骨髓瘤(MM)的临床特点,研究MM肾病发生的相关因素。方法对医院收治的48例MM肾病患者的临床资料进行总结分析。结果 48例患者,男27例,女21例,中位年龄为58岁,临床表现为不同程度的贫血、蛋白尿、溶骨性损害。骨髓液中浆细胞数与肾功能损害有明显相关性(P<0.01),贫血、高钙血症、高β2微球蛋白水平及高血尿酸与MM肾脏损害有相关关系。结论 MM肾病的临床表现多样性,浆细胞数量、贫血、高钙血症、高β2微球蛋白水平及高尿酸可能与MM肾病发生有关。
Objective Research the clinical characteristics and the etiological factor of Multiple myeloma. Methods The clinical data of 48 cases of multiple myeloma nephropathy were analyzed retrospectively. Results In 48 patients,male 27 cases,female 21 cases,median age 58 years. The clinical manifestations are different degrees of anaemia,albuminuria and osteolytic lesions. There was significant correlation between the number of plasma cells and renal function damage in bone marrow. Multiple myeloma kidney damage was associated with Anemia,hypercalcemia,high β2-microglobulin level,high level of serum uric acid and high uric acid. Conclusion Clinical manifestations of Multiple myeloma kidney damage are varied,and it was associated with Anemia,hypercalcemia,high β2-microglobulin level,high level of serum uric acid and high uric acid.
出处
《临床合理用药杂志》
2014年第23期6-7,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
多发性骨髓瘤
肾损害
临床特点
危险因素
Multiple myeloma
Kidney damage
Clinical characteristics
Risk factors
