中药对骨髓间充质干细胞增殖、凋亡及分化的影响研究进展

Research progress on effects of traditional Chinese medicines on proliferation,apoptosis and differentiation of bone marrow mesenchymal stem cells

骨髓间充质干细胞(bone marrow mesenchymal stem cells,BMSCs)是一类来源于骨髓的多能干细胞,不仅能够提供造血支持,且具有自我更新、高度增殖以及多向分化的潜能,是目前干细胞研究的热点。近年来,科研人员就中药对BMSCs的影响开展了一系列的研究,发现有的中药能够促进BMSCs的增殖,有的则能够抑制其凋亡,还有的能够诱导其向成骨细胞、软骨细胞等多个方向分化。其中,部分研究还就作用机制进行了探讨,作者对其研究进展进行了概述。

Bone marrow mesenchymal stem cells（BMSCs） are a kind of pluripotent stem cells derived from bone marrows,which can not only support hematopoiesis,but also have capabilities of multidifferentiation,high-proliferation and self-renewing.They have become one of hotspots in stem cell studies.Studies on in vitro intervention with BMSCs with TCMs have made remarkable progress in recent years.According to the findings,some traditional Chinese medicines can promote proliferation of BMSCs,some can inhibit the apoptosis of BMSCs,while others can induce BMSCs to differentiate into multiple cell types,such as osteoblast.Furthermore,some studies also involved relevant action mechanisms.The authors summarized the advance in relevant studies by reference to relevant literatures of this field.