右美托咪定喷鼻用于小儿核磁共振检查镇静效果的观察

Observation on the sedative effect of intranasal dexmedetomidine used for MRI scanning in children

目的：探讨右美托咪定喷鼻用于小儿核磁共振检查镇静效果。方法：选择MRI检查的患儿40例,随机分为两组,每组20例：水合氯醛组（A组）和右美托嘧啶组（B组）。A组患儿以10%水合氯醛50-80 mg/kg灌肠,B组以1.5μg/kg右美托咪定喷鼻。监测并比较两组患儿用药前与用药后的心率（HR）、血氧饱和度（SpO2）、呼吸频率（RR）;观察镇静效果,并进行Ramsay镇静评分并记录不良反应。结果：两组患儿用药后均能完成检查,但B组的镇静效果优于A组且未发生不良反应;A组不能配合给药3例,发生轻度恶心1例。结论：右美托咪定喷鼻用于小儿核磁共振检查镇静时,药物起效快、效果确切、不良反应少,值得在临床上推广应用。

Objective： To explore the sedative effect of intranasal dexmedetomidine used for MRI scanning in children. Methods： Forty children undergoing MRI scanning were randomly divided into two groups, 20 children in each group; the children in group A were treated with 10% chloral hydrate as enema （50 -80 mg/kg）, while the children in group B were treated with intranasal dexmedetomidine （1.5 μg/kg） . Heart rates, oxyhemoglobin saturations and respiratory rates before and after treatment in the two groups were monitored and compared; the sedative effects in the two groups were observed; Ramsay scores were obtained and the adverse reactions were recorded. Resuits： MRI scanning was completed in the two groups after treatment, but the sedative effect in group B was better than that in group A, no adverse reaction occurred in group B; while in group A, 3 children couldnt cooperate the treatment, and one child was found with mild nausea. Conclusion： Intranasal dexmedetomidine used for MRI scanning in children has the advantages of taking action fast, good sedative effect and few adverse reactions, which is worth clinical popularizing and applying.