拉米夫定联合膈下逐瘀汤对乙型肝炎肝硬化治疗的临床疗效评价

Clinical effect evaluation of lamivudine combined with gexiazhuyu soup in treatment of HBV-induced liver cirrhosis

目的观察拉米夫定联合膈下逐瘀汤治疗乙型肝炎肝硬化的效果,以改善肝功能。方法选取2009年1月50例乙型肝炎肝硬化患者,分为治疗组与对照组,各25例;治疗组应用拉米夫定联合膈下逐瘀汤治疗;对照组单用拉米夫定进行治疗;观察并比较两组在治疗前后肝功能、肝纤维化指标、门静脉血流动力学、血清HBV-DNA等,并进行Child-Pugh分级评分,应用SPSS13.0软件进行统计分析。结果经过治疗两组患者的肝功能指标明显改善,肝纤维化指标有所下降,门静脉血流动力学的指标也明显改善,HBV-DNA载量下降,Child-Pugh评分有所下降,对照组由(9.3±2.6)分降至(6.2±2.1)分;与对照组相比,治疗组在以上各项指标的改善均更加明显,Child-Pugh评分治疗组为(6.2±2.1)分,对照组为(8.1±2.4)分,差异均有统计学意义(P<0.05)。结论拉米夫定联合膈下逐瘀汤治疗乙型肝炎肝硬化的效果更加明显,优于单用拉米夫定。

OBJECTIVE To observe the effect of lamivudine combined with gexiazhuyu soup in treatment of HBV- induced liver cirrhosis to improve liver function. METHODS Totally 50 patients with HBV-induced liver cirrhosis in our hospital in Jan. 2009 were selected and divided into the treatment group and the control group, each group with 25 patients. The treatment group received combined treatment of lamivudine with gexiazhuyu soup, while the control group received lamivudine only. The two groups were observed for the changes of liver function before and after treatment, the indicator of liver fibrosis, portal vein hemodynamics, and HBV-DNA, were scored with the Child-Pugh grading. The statistical analysis was conducted with SPSS 13.0. RESULTS After the treatment, liver function and the indicator for portal vein hemodynamics were significantly improved and the indicator of liver fibrosis, HBV-DNA loading capacity and Child-Pugh scores were deceased at certain degrees. The Child-Pugh score was decreased from （9. 3 ±2.6） to （6.2 ±2. 1） in the control group. Compared with the control group, the improvement of the above indicators in treatment group was more obvious. The Child-Pugh score was （6.2±2.1） in the treatment group and （8.1±2.4） in the control group with significant difference （P〈0.05）. CONCLUSION Lamivudine combined with gexiazhuyu soup has more obvious efficacy in treatment of HBV-induced liver cirrhosis, superior to lamivudine alone.